| 高血压脑出血患者血肿周围血-脑屏障超微结构的观察 |
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| 引用本文： | 李中秋,陆兵勋. 高血压脑出血患者血肿周围血-脑屏障超微结构的观察[J]. 临床神经病学杂志, 2005, 18(4): 297-298 |
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| 作者姓名： | 李中秋 陆兵勋 |
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| 作者单位： | 510515广州,南方医科大学南方医院神经内科;510515广州,南方医科大学南方医院神经内科 |
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| 摘 要： | 目的 动态观察高血压脑出血后不同时间血肿周围血-脑屏障（BBB）的超微结构。方法 选取10例基底节区高血压脑出血患者，通过CT导向脑立体定向仪在血肿周围取脑组织标本，电镜下观察BBB的超微结构。结果：脑出血12h后BBB胶质足板水肿，胞饮水泡增多，24h后内皮细胞线粒体肿胀，嵴断裂，48h后足板水肿明显，内皮细胞水肿，细胞核增大；72h胞质稀疏，基底膜断开；5d内皮细胞胞膜及核膜溶解，毛细血管塌陷。结论 脑出血早期预防BBB的损害是治疗脑出血的重要方面。
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| 关 键 词： | 脑出血 血-脑屏障 超微结构 |
| 文章编号： | 1004-1648（2005）04-0297-02 |
| 收稿时间： | 2004-07-22 |
| 修稿时间： | 2004-11-04 |
Observation on ultrastructure of blood-brain barrier around hematoma in patients with hypertensive cerebral hemorrhage |
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| LI Zhong-qiu,LU Bing-xun. Observation on ultrastructure of blood-brain barrier around hematoma in patients with hypertensive cerebral hemorrhage[J]. Journal of Clinical Neurology, 2005, 18(4): 297-298 |
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| Authors: | LI Zhong-qiu LU Bing-xun |
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| Abstract: | Objective To observe the ultrastructure of blood-brain barrier (BBB) around hematoma in patients with hypertensive intracerebral hemorrhage (ICH).Methods Brain tissue around hematoma in 10 patients with hypertensive ICH was obtained using stereotaxic apparatus targeted by CT scan. Ultrastructure of BBB was observed under electron microscope. Results Astrocytic end feet swelled and pinocytotic vesicles increased 12 h after ICH. Mitochondrion of endothelial cells swelled and ridges disrupted 24 h after ICH. Astrocytic end feet and endothelial cells showed apparent edema, cell nuclei tumefied 48 h after ICH. Cytoplasm loosened and fundus membranes ruptured 72 h after ICH. Endothelial cell membranes and nuclei dissolved and capillary vessels dented 5 d after ICH. Conclusion Prevention of BBB from damage is important in treating ICH at early stage. |
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| Keywords: | cerehral hemorrhage bloud-brain barrier ultrastructure |
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