Alkaline phosphatase positive precursors of adipocytes in the human bone marrow |
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| Authors: | P. Bianco M. Costantini L. C. Dearden E. Bonucci |
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| Affiliation: | Department of Human Biopathology, La Sapienza University, Rome, Italy. |
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| Abstract: | Developing fat cells in the bone marrow of leukaemic patients treated with chemotherapy were found to be endowed with membrane-bound alkaline phosphatase. Since alkaline phosphatase is a cytochemical marker of 'reticular' cells, this observation provides cytochemical evidence that reticular cells may convert to adipocytes when marrow cellularity abruptly decreases. |
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