| 鼻腔应用类固醇激素对鼻黏膜辐射性损伤组织形态学变化的影响 |
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| 引用本文： | 朱新华,刘月辉.鼻腔应用类固醇激素对鼻黏膜辐射性损伤组织形态学变化的影响[J].临床耳鼻咽喉头颈外科杂志,2009,23(8):364-368. |
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| 作者姓名： | 朱新华 刘月辉 |
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| 作者单位： | 南昌大学第二附属医院耳鼻咽喉-头颈外科,南昌,330006 |
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| 摘 要： | 目的：观察辐射后鼻腔应用类固醇激素对鼻黏膜辐射性损伤组织形态学变化的影响，探讨鼻腔应用类固醇激素在鼻黏膜辐射性损伤中的作用。方法：选用健康豚鼠50只，用医用直线加速器进行鼻部照射，照射剂量为5Gy，每周1次，共3周，在完成辐射后随机分为对照组及用药组，每组25只，用药组在照射完成后第2天开始鼻腔应用类固醇激素。各组分别于照射后1周及1、2、3、4个月各随机处死5只动物，光镜及电镜下观察鼻黏膜的病理学变化及显微图像学分析。结果：照射后喷药，豚鼠鼻黏膜早期炎症反应减轻，并随喷药时间延长，损伤的上皮细胞修复加快，4个月后纤毛覆盖率达72．9％，比单纯照射豚鼠鼻黏膜纤毛覆盖率50．2％明显升高，且黏膜下腺体萎缩减轻，表现出一定的分泌功能。结论：鼻腔应用类固醇激素减轻了鼻黏膜辐射性损伤，在鼻黏膜组织辐射性损伤中起到了一定的保护作用。
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| 关 键 词： | 鼻黏膜 电离辐射 类固醇激素 组织病理学 |
Effects of intranasal corticosteroids on radiated nasal mucosa of guinea pig |
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| ZHU Xinhua,LIU Yuehui.Effects of intranasal corticosteroids on radiated nasal mucosa of guinea pig[J].Journal of Clinical Otorhinolaryngology,2009,23(8):364-368. |
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| Authors: | ZHU Xinhua LIU Yuehui |
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| Institution: | Department of Otolaryngology-Head and Neck Surgery;the Second Affiliated Hospital;Nanchang University;Nanchang;330006;China |
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| Abstract: | Objective:To observe histopathologic changes of irradiated guinea pigs' nasal mucosa treated with intranasal corticosteroids and to study the radioprotective effect of intranasal corticosteroids.Method:Fifty health guinea pigs' nasal parts were performed irradiation by the WDVE-6MeV linear accelerator.They had accepted 5 Gy one time per week for three weeks through X-ray irradiating to establish the animal irradiation injury model.After that,they were divided into 2 groups randomly:the control group and the... |
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| Keywords: | nasal mucosa irradiation intranasal corticosteroids histopathology |
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