| 康莱特注射液对肿瘤恶病质实验模型的细胞免疫功能影响 |
| |
| 引用本文： | 邓松华 徐振山. 康莱特注射液对肿瘤恶病质实验模型的细胞免疫功能影响[J]. 中国药理学通报, 1998, 14(5): 445-447 |
| |
| 作者姓名： | 邓松华 徐振山 |
| |
| 作者单位： | 安徽医科大学病理生理学教研室!合肥，320032，安徽省蚌埠医学院免疫学教研室!蚌埠，233000，安徽省肿瘤医院外科!蚌埠，233000，安徽医科大学病理生理学教研室!合肥，320032 |
| |
| 摘 要： | 目的探讨癌症恶病质时机体细胞免疫功能变化及康莱特（kanglaite，KLT）对癌症恶病质的治疗作用。方法建立T739小鼠癌症恶病质模型，观察KLT对模型鼠细胞免疫功能的作用。结果KLT可明显降低小鼠血清中肿瘤坏死因子（TNF-α）水平，并可提高NK细胞活性和促进小鼠脾淋巴细胞增殖。结论康莱特对小鼠癌症恶病质时受损的细胞免疫功能有较好的恢复作用。
|
| 关 键 词： | 癌症恶病质 康莱特治疗 TNF-α NK细胞 淋巴细胞增殖 |
Effect of kanglate injuction on cellular immunological function of tumor cachexia modeal |
| |
| DENG Song-Hua, XU Zheng-Shan, LIU Ai-Guo, ZHANG Bac-Ting. Effect of kanglate injuction on cellular immunological function of tumor cachexia modeal[J]. Chinese Pharmacological Bulletin, 1998, 14(5): 445-447 |
| |
| Authors: | DENG Song-Hua XU Zheng-Shan LIU Ai-Guo ZHANG Bac-Ting |
| |
| Abstract: | AIM To investigate the change of cellular immunological function during cancer cachexia and the therapeutic effect of kanglaite (KLT) for the cachexia. METHODS T739 murine model of cancer cachexia was established to observe the effect of KLT on the cellular immunological function of the mouse. RESULTS KLT markedly decreased the serum TNF-α level of the mice and increased NK cell activity as well as promoted the spleen lymphocyte proliferation of the mouse. CONCLUSIONS It is suggested that that KLT might have some effects on improving the impaired immune function of the mouse in cancer cache-cia. |
| |
| Keywords: | cancer cachexia KLT therapy TNF-α NK cell lymphocyte proliferation |
| 本文献已被 CNKI 维普 等数据库收录！ |
