硫酸奈替米星在大鼠体内的药代动力学 |
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引用本文: | 袁成,王景祥.硫酸奈替米星在大鼠体内的药代动力学[J].中国药理学通报,1998,14(2):180-182. |
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作者姓名: | 袁成 王景祥 |
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作者单位: | 济南军区总医院药理科 |
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摘 要: | 目的研究硫酸奈替米星在大鼠体内分布和排泄情况。方法大鼠iv给药后,采用高效液相色谱-间接光度检测(HPLC-IPD)法测定组织和体液中药物浓度,并计算药动学参数。结果血药浓度-时间曲线符合一室开放模型,不同给药剂量时其体内T1/2为3.01~3.62h;组织中药物浓度以肝、脾、肺、肾中最高,脂肪和脑中较低;平均血浆蛋白结合率为6.8%~17.4%;尿、粪和胆汁24h排泄原型药物量占给药量的74.7%,1.70%和4.84%。结论硫酸奈替米星在大鼠体内组织分布具有选择性,蛋白结合率低,主要经肾脏以原型排泄。
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关 键 词: | 奈替米星 药代动力学 高效液相色谱-间接光度检测法 |
Pharmacokinetics of netilmicin sulfate in rats |
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Abstract: | AIM To investigate the pharmacokinetic of netilmicin sulfate in rats. METHODS The concentration of netilmicin sulfate was detected by a high performance liquid chromatography indirect photometric determination (HPLC IPD) method. RESULTS After intramuscutar injection netilmicin sulfate, the data obtained were fitted with 3P87 pharmacokinetic program. The dispostion was conformed to a single compartment model with T1/2=301 ̄362 h at single dose. The binding percentage of the drug to plasma protein was 68% ̄174%. There was a highest drug accumulation in liver, lung and kidney, and a lowest in fat and brain. It excreted in urine, feces and bile within 24 h was 747%, 170% and 484%. CONCLUSION Netilmicin sulfate in rats is noted for its characteristic of distributed in tissues selectively, lower binding percentage to protein and excreted with prototype in kidney mainly. |
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Keywords: | netilmicin sulfate pharmacokinetics HPLC IPD |
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