| 异紫堇啡碱对血管平滑肌钙内流和钙释放的影响 |
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| 引用本文： | 蒋青松 黄燮南. 异紫堇啡碱对血管平滑肌钙内流和钙释放的影响[J]. 中国药理学通报, 1998, 14(6): 546-548 |
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| 作者姓名： | 蒋青松 黄燮南 |
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| 作者单位： | 遵义医学院药理学教研室，重庆医科大学药理学教研室 |
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| 摘 要： | 目的研究异紫堇啡碱（ＩＳＯＣ）对血管平滑肌钙内流和钙释放的影响，以初步阐明其作用方式。方法利用兔胸主动脉螺旋条标本观察ＩＳＯＣ对去甲肾上腺素（ＮＡ）及ＫＣｌ量效曲线的影响和对无钙液中ＮＡ、ＣａＣｌ２复钙、咖啡因缩血管效应的影响。结果ＩＳＯＣ１０μｍｏｌ·Ｌ－１对ＮＡ的量效曲线呈非竞争性拮抗作用，而对高钾的作用则不明显。在无钙液中，ＩＳＯＣ１００μｍｏｌ·Ｌ－１能明显抑制ＮＡ所致的收缩及复钙后外钙内流诱发的收缩，ＩＳＯＣ１０及３０μｍｏｌ·Ｌ－１则只作用于前者；各实验浓度的ＩＳＯＣ对咖啡因在无钙液中的缩血管作用均无影响。结论ＩＳＯＣ抑制受体中介的钙释放和钙内流，但不是典型的钙拮抗剂。
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| 关 键 词： | 异紫堇啡碱；去甲肾上腺素；钙释放；钙内流；兔胸主动脉 |
Effects of isocorydine on Ca 2 influx and Ca 2 release in rabbit aortic smooth muscle |
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| JIANG Qing Song,HUANG Xie Nan,SUN An Sheng,WU Qing,XIE Xiao Long. Effects of isocorydine on Ca 2 influx and Ca 2 release in rabbit aortic smooth muscle[J]. Chinese Pharmacological Bulletin, 1998, 14(6): 546-548 |
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| Authors: | JIANG Qing Song HUANG Xie Nan SUN An Sheng WU Qing XIE Xiao Long |
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| Abstract: | AIM To research the vasodilative mechanism(s) of isocorydine (ISOC), its effects on Ca 2+ influx and Ca 2+ release in blood vessel smooth muscle were investigated. METHODS The effects of ISOC on the concentration contraction curves for noradrenaline(NA) and high potassium were compared, and its effects on the contractions induced by NA, CaCl 2 and caffine in the Ca 2+ free medium were surveied with rabbit aortic strips. RESULTS ISOC at 10 μmol·L -1 inhibited CONCLUSION ISOC can inhibit the receptor mediated Ca 2+ influx and Ca 2+ release, but it is not a classical Ca 2+ antagonist. |
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| Keywords: | isocorydine noradrenaline Ca 2 release Ca 2 influx rabbit aorta |
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