Technetium-99m hexamethyl propylene amine oxine leucocytes in the assessment of disease activity in inflammatory bowel disease |
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| Authors: | Eila Lantto Kari Järvi Iikka Krekelä Tuomo Lantto Matti Taavitsainen Heikki Vedenkangas Martti Vorne |
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| Affiliation: | (1) Department of Radiology, Päijät-Häme Central Hospital, Keskussairaalankatu 7, SF-15850 Lahti, Finland;(2) Department of Pathology, Päijät-Häme Central Hospital, Keskussairaalankatu 7, SF-15850 Lahti, Finland;(3) Department of Internal Medicine, Päijät-Häme Central Hospital, Keskussairaalankatu 7, SF-15850 Lahti, Finland;(4) Department of Nuclear Medicine, Päijät-Häme Central Hospital, Keskussairaalankatu 7, SF-15850 Lahti, Finland;(5) Department of Diagnostic Radiology, Helsinki University Central Hospital, Helsinki, Finland |
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| Abstract: | The inflammatory activity in 108 bowel segments of 40 patients with suspected or known inflammatory bowel disease was assessed macroscopically by endoscopy, histology and technetium-99m hexamethyl propylene amine oxine (99mTc-HMPAO) leucocytes using a numerical grading system (scores 0–3). A 4-h series of scintigrams showed a significant correlation with both histological and macroscopical assessment of disease activity (rho = 0.850, P<0.001 and rho = 0.773, P<0.001, respectively). Sensitivity, specificity and accuracy of scintigraphy in detecting active inflammatory segments were 85%, 92% and 89%, respectively. A normal scintigram did not completely exclude mild inflammatory activity, especially in the rectosigmoid area. 99mTc-HMPAO leucocytes offer an accurate and non-invasive alternative for the assessment of disease activity in ulcerative colitis and Crohn's disease.Offprint requests to: E. Lantto |
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| Keywords: | Inflammatory bowel disease Crohn's disease Ulcerative colitis technetium-99m hexamethyl propylene amine oxine (99mTc-HMPAO) leucocytes Inflammatory activity |
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