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| FIL-6与TNF—α、TGF—β在EAE大鼠表达的相关性分析 | |
| 引用本文： | 段大志,刘勇,梁丽云,马存根. FIL-6与TNF—α、TGF—β在EAE大鼠表达的相关性分析[J]. 中国医师杂志, 2008, 10(10): 1314-1317 |
| 作者姓名： | 段大志 刘勇 梁丽云 马存根 |
| 作者单位： | 1. 山西大同大学脑科学研究所,山西,大同,037008;第三军医大学新桥医院神经内科 2. 第三军医大学新桥医院神经内科 3. 山西大同大学脑科学研究所,山西,大同,037008 |
| 基金项目： | 山西省留学回国人员科研启动基金，国家人口和计划生育委员会科研资助项目 |
| 摘 要： | 目的探索IL-6在实验性自身免疫性脑脊髓炎（EAE）中的作用机制。方法将25只雌性Wistar大鼠随机分为EAE组（n=15）、对照组（n=10）。利用免疫组化染色技术观察IL-6、TNF-α、TGF—β的表达，进行相关性分析。结果IL-6灰度值与症状评分呈负相关（r=-0．953，P〈0．05）、与TNF-α呈正相关（r=0．967，P〈0．05），IL-6与TGF—β呈无相关（r=-0．492，P〉0．05）.TNF—α灰度值与症状评分呈负相关（r=-0．978，P〈0．05），TNF—α与TGF—β无相关（r=-0．502，P〉0．05）。TGF-β灰度值与症状评分无相关（r=0．470，P〉0．05）。结论IL-6参与EAE的过程，可能是一种致炎因子。 |
| 关 键 词： | 脑脊髓炎,实验性自身免疫性 白细胞介素6 肿瘤坏死因子 转化生长因子β |
Correlation Analysis of the Expressions of IL-6 , TNF-αand TGF-β in Experimental autoimmune Encephalomyelitis in Rats |
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| DUAN Da-zhi,LIU Yong,LIANG Li-yun,MA Cun-gen. Correlation Analysis of the Expressions of IL-6 , TNF-αand TGF-β in Experimental autoimmune Encephalomyelitis in Rats[J]. Journal of Chinese Physician, 2008, 10(10): 1314-1317 | |
| Authors: | DUAN Da-zhi LIU Yong LIANG Li-yun MA Cun-gen |
| Affiliation: | DUAN Da-zhi, LIU Yong, LIANG Li-yun ,MA Cun-gen.( Institute of Brain Science, Shanxi Datong University, Datong 037008, China ) |
| Abstract: | Objective To explore the mechanism of IL-6 in EAE. Methods 25 female Wistar rats were randomly divided into 2 groups, EAE group( n=15 ) and normal control group( n=10). The expression of IL-6, TNF-αtand TGF-β of the two groups rots were ob-served by immunohistochemistry staining, and then correlation analysis of the expression of IL-6, TNF-αtandTGF-β was made. Results There was negative correlation between gray scale of IL-6 and symptom scores( r=-0.953, P＞0.05). IL-6 and TGF-β had no statistical-ly significant correlation ( r=-0.492, P＞0.05). There was negative correlation between gray scale of TNF-α and symptom scores( r=-0.978, P＜0.05), and both of the correlation between TNF-α and TGF-β ( r=-0.502, P＞0.05), TGF-β and scores( r=0.470,P＞0.05 ) were not statistically significant. Conclusions IL-6 may participate in EAE as a inflammatory factor. |
| Keywords: | Encephalomyelitis,experimental autoimmune Interleukin-6 Tumor necrosis factor Transforming growth factor beta |
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