| IL—6基因转染的骨髓基质细胞系对骨髓移植小鼠造血功能恢复？… |
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| 引用本文： | 秦凤华 谢蜀生. IL—6基因转染的骨髓基质细胞系对骨髓移植小鼠造血功能恢复？…[J]. 中华血液学杂志, 1998, 19(11): 583-586 |
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| 作者姓名： | 秦凤华 谢蜀生 |
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| 摘 要： | 目的：探讨白细胞介素６（ＩＬ－６）基因转染的骨髓基质细胞系ＱＸＭＳＣ１ＩＬ－６对骨髓移植后造血功能的重建作用。方法：将骨髓造血细胞和骨髓基质细胞系一起经尾静脉注射给同系小鼠，建立骨髓移植（ＢＭＴ）模型。小鼠的造血功能用脾结节（ＣＦＵ－Ｓ）、粒－单系祖细胞（ＣＦＵ－ＧＭ）、红系祖细胞（ＣＦＵ－Ｅ、ＢＦＵ－Ｅ）测定及外周血各项血液学指标来确定。结果：ＷＸＭＳＣ１ＩＬ－６转基因骨髓基质细胞可明显增强ＢＭ
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| 关 键 词： | 白细胞介素6 基因转移 骨髓移植 造血功能 |
Effect of the IL-6 transfected bone marrow stromal cells on the recovery of hematopoietic functions in bone marrow transplanted mice] |
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| F Qin,S Xie. Effect of the IL-6 transfected bone marrow stromal cells on the recovery of hematopoietic functions in bone marrow transplanted mice][J]. Chinese Journal of Hematology, 1998, 19(11): 583-586 |
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| Authors: | F Qin S Xie |
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| Affiliation: | Department of Immunology, Beijing Medical University, Beijing 100083. |
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| Abstract: | OBJECTIVE: To study the effect of the IL-6 transfected bone marrow stromal cell, QXMSC1 IL-6, on the hematopoietic reconstitution in bone marrow transplanted mice. METHODS: Bone marrow transplantation model was established by infusing hematopoietic cells combined with QXMSC1 IL-6 into syngeneic recipient mice through the tail vein. CFU-S, CFU-GM, CFU-E, BFU-E, and peripheral blood pictures were assayed. RESULTS: QXMSC1 IL-6 could increase the CFU-S, CFU-GM, CFU-E and BFU-E yields in BMT mice, and accelerate the recovery of peripheral blood cells. CONCLUSION: QXMSC1 IL-6 can improve the hematopoietic reconstitution in bone marrow transplanted mice. |
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