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Sp1 is an essential transcription factor for LPS-induced tissue factor expression in THP-1 monocytic cells, and nobiletin represses the expression through inhibition of NF-kappaB, AP-1, and Sp1 activation
Authors:Hirata Yuki  Masuda Yutaka  Kakutani Hideki  Higuchi Toshiyuki  Takada Kimihiko  Ito Akira  Nakagawa Yoshio  Ishii Hidemi
Affiliation:Department of Molecular and Cellular Pathophysiology, Showa Pharmaceutical University, Higashi Tamagawa Gakuen, Machida, Tokyo 194-8543, Japan.
Abstract:
Keywords:Nobiletin   Tissue factor   LPS   NF-κB   AP-1   Sp1
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