| 雌二醇预处理对离体大鼠缺血-再灌注心肌细胞Ca2+和肌钙蛋白Ⅰ的影响 |
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| 引用本文： | 王伟 李淳成 王慧芳. 雌二醇预处理对离体大鼠缺血-再灌注心肌细胞Ca2+和肌钙蛋白Ⅰ的影响[J]. 郑州大学学报(医学版), 2004, 39(2): 293-295 |
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| 作者姓名： | 王伟 李淳成 王慧芳 |
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| 作者单位： | 王伟（西安交通大学第二医院外科,西安,710003）;李淳成（西安交通大学第二医院外科,西安,710003）;王慧芳（河南科技大学第一附属医院麻醉科,洛阳,471003） |
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| 摘 要： | 目的探讨雌二醇预处理对离体大鼠缺血-再灌注心肌细胞Ca2+和肌钙蛋白Ⅰ(TnI)的影响.方法采用Langendorff装置建立大鼠离体心脏缺血-再灌注模型,将24只雄性大鼠随机分为对照、治疗及预处理组.治疗组在缺血期给雌二醇3.3 mg·L-1,预处理组于灌注期给予雌二醇3.3 mg·L-1,对照组不给药.观察心肌细胞内Ca2+含量和心脏灌洗液中TnI含量的变化.结果再灌注结束后,预处理组心肌细胞内Ca2+水平低于对照组和治疗组(P＜0.01或0.05).预处理组缺血早期心脏灌注液中TnI含量低于其他2组(P＜0.05),在缺血及再灌注期,预处理组及治疗组TnI含量均低于对照组.电镜观察预处理组心肌细胞损伤小于其他2组.结论雌二醇预处理对缺血-再灌注心肌具有更好的保护作用.
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| 关 键 词： | 雌二醇 缺血—再灌注 预处理 心肌细胞Ca^2＋ 肌钙蛋白I |
| 修稿时间： | 2003-03-04 |
Effect of estradiol preconditioning on intracellular Ca~(2+) and troponin I in myocardium of isolated ischemic/reperfusion rat heart |
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| WANG Wei,LI Chuncheng,WANG Huifang. Effect of estradiol preconditioning on intracellular Ca~(2+) and troponin I in myocardium of isolated ischemic/reperfusion rat heart[J]. Journal of Zhengzhou University: Med Sci, 2004, 39(2): 293-295 |
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| Authors: | WANG Wei LI Chuncheng WANG Huifang |
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| Affiliation: | WANG Wei,LI Chuncheng,WANG HuifangDepartment of Surgery,the Second Hospital,Xian Jiaotong University,Xian 710003 Departmentof Anesthesia,the First Affiliated Hospital,Henan Science and Technology University,Luoyang 471003 |
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| Abstract: | Aim: To observe the effect of estradiol preconditioning on intracellular Ca2+ and troponin 1 in myocardium of isolated ischemic/reperfusedrats. Methods: The instrument of Langendorff was used to establish the model of isolated is-chemic/reperfusion heart and male rats were divided into three groups randomly; control, treatment and precondition groups. Results: Compared with control and treatment groups, estradiol preconditioning decreased the content of intracel-lular Ca2+ and decomposion of Tnl more effectively. Conclusion : Estradiol preconditioning can produce more protective effect on myocardium of isolated ischemic/reperfusion rat heart. |
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| Keywords: | estradiol ischemic reperfusion preconditioning intracellular Ca2+ troponin I |
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