| 131I难治性分化型甲状腺癌的再分化治疗 |
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| 引用本文： | 程凌霄,陈立波. 131I难治性分化型甲状腺癌的再分化治疗[J]. 中国癌症杂志, 2016, 26(1): 35-42. DOI: 10.3969/j.issn.1007-3969.2016.01.006 |
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| 作者姓名： | 程凌霄 陈立波 |
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| 作者单位： | 上海交通大学附属第六人民医院核医学科，上海 200233 |
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| 基金项目： | 国家自然科学基金，上海市科技启明星 |
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| 摘 要： | 131I难治性分化型甲状腺癌(radioiodine-refractory differentiated thyroid cancer，RR-DTC)是目前甲状腺癌临床治疗领域的一大难题。维甲酸类药物、过氧化物酶体增殖物激活受体激动剂、DNA甲基化酶抑制剂及组蛋白脱乙酰化酶抑制剂都曾被用于诱导RR-DTC再分化并与131I联合治疗，但疗效并不显著。近年来，随着对RR-DTC分子机制认识的不断深入，靶向治疗等新的再分化治疗策略越来越多地被尝试用于治疗RRDTC。相比之下，分子靶向药物用于诱导RR-DTC重摄碘及介导131I治疗效果较好，可能具有良好的应用前景。
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| 关 键 词： | 甲状腺癌 再分化治疗 靶向药物 131I |
Re-differentiating therapy of radioiodine-refractory differentiated thyroid cancer |
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| CHENG Lingxiao,CHEN Libo. Re-differentiating therapy of radioiodine-refractory differentiated thyroid cancer[J]. China Oncology, 2016, 26(1): 35-42. DOI: 10.3969/j.issn.1007-3969.2016.01.006 |
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| Authors: | CHENG Lingxiao CHEN Libo |
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| Affiliation: | Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China |
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| Abstract: | Clinical management of radioiodine-refractory differentiated thyroid cancer (RR-DTC) is extremely diffcult. Re-differentiation compounds, such as retinoids, peroxisome proliferator-activated receptor (PPAR) agonists, DNA methyltransferase inhibitors and histone deacetylase inhibitors, have been used in trials to increase iodine uptake in RR-DTC. However, data on these drugs failed to meet the initial high expectations. In recent years, targeted agents have been increasingly used in pre-clinical and clinical studies to induce re-differentiation and mediate131I therapy, and the outcomes are encouraging. |
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| Keywords: | Thyroid cancer Re-differentiating therapy Targeted agents 131I |
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