| Pharmacokinetics of Controlled Release and Immediate Release Morphine Sulphate Tablets after a Single Dose and Multiple Doses in Chinese Volunteers |
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| 作者姓名： | 邓艳萍 王凯 刘立京 刘静雯 蔡志基 楼雅卿 |
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| 作者单位： | 北京医科大学中国药物依赖性研究所 |
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| 摘 要： | 健康志愿者１０名，随机交叉口服硫酸吗啡控释片（ＣＲＭＳ）３０ｍｇ（３０ｍｇ×１）和硫酸吗啡普通片（ＩＲＭＳ）２０ｍｇ（１０ｍｇ×２），分别于服药前后各时点取静脉血，用ＧＣＭＳ测定血浆中吗啡含量。以药代软件程序处理，分别求得ＣＲＭＳ和ＩＲＭＳ的Ｃｍａｘ为１９．３８±３．８０和２１．２７±６．２１ｎｇ／ｍｌ；ｔｍａｘ为２．３６±０．３７ｈ和０．５５±０．１６ｈ；ｔ１／２β为３．５３±０．８７ｈ和３．０３±０．７４ｈ，曲线下面积ＡＵＣ为１４５．１５±１７．６５和９３．０８±１６．６５ｎｇ·ｈ／ｍｌ。癌症病人多次口服硫酸吗啡至稳态，ＣＲＭＳ和ＩＲＭＳ的峰浓度分别为２７．４３±０．３３ｎｇ／ｍｌ，２２．６８±０．１６ｎｇ／ｍｌ；谷浓度分别为１９．４５±１．４４ｎｇ／ｍｌ；１８．１４±０．４９ｎｇ／ｍｌ。
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| 关 键 词： | 硫酸吗啡控释片 硫酸吗啡普通片 药代动力学 单次给药 多次给药 GC-MS |
Pharmacokinetics of Controlled Release and Immediate Release Morphine Sulphate Tablets after a Single Dose and Multiple Doses in Chinese Volunteers |
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| Yan Ping Deng,Kai Wang,Li Jing Liu,Jing Wen Liu,Zhi Ji Cai and Ya Qing Lou National Institute of Drug Dependence,Beijing Medical University,Beijing.Pharmacokinetics of Controlled Release and Immediate Release Morphine Sulphate Tablets after a Single Dose and Multiple Doses in Chinese Volunteers[J].Journal of Chinese Pharmaceutical Sciences,1997(4). |
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| Authors: | Yan Ping Deng Kai Wang Li Jing Liu Jing Wen Liu Zhi Ji Cai and Ya Qing Lou National Institute of Drug Dependence Beijing Medical University Beijing |
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| Institution: | Yan Ping Deng,Kai Wang,Li Jing Liu,Jing Wen Liu,Zhi Ji Cai and Ya Qing Lou National Institute of Drug Dependence,Beijing Medical University,Beijing 100083 |
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| Abstract: | |
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| Keywords: | Controlled release morphine sulphate tablet Immediate release morphine sulphate tablet Pharmacokinetics Single dose Multiple doses GC MS |
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