Post-cholecystectomy Quality of Life: A Prospective Multicenter Cohort Study of Its Associations with Preoperative Functional Status and Patient Demographics |
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Authors: | Hon-Yi Shi King-Teh Lee Hao-Hsien Lee Yih-Huei Uen Jinn-Tsong Tsai Chong-Chi Chiu |
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Institution: | (1) Graduate Institute of Healthcare Administration, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, 80756 Kaohsiung, Taiwan;(2) Division of Hepatobiliary Surgery, Department of Surgery, Kaohsiung Medical University Hospital, 100, Zihyou 1st Road, 807 Kaohsiung, Taiwan;(3) Department of General Surgery, Chi Mei Medical Center, 201, Taikang Village, Liou Ying Township, 736 Tainan, Taiwan;(4) Chia Nan University of Pharmacy and Science, Tainan, Taiwan;(5) Taipei Medical University, Taipei, Taiwan;(6) Department of Computer Science, National Pingtung University of Education, 4-18, Ming Shen Road, 900 Pingtung, Taiwan; |
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Abstract: | Purpose This study analyzed patient demographics and preoperative functional status for associations with post-cholecystectomy quality
of life (QOL).
Methods This prospective study analyzed 159 cholecystectomy patients at two tertiary academic hospitals. All patients completed the
SF-36 and the gastrointestinal quality of life index (GIQLI) at baseline and at 3 and 6 months postoperatively. The 95% confidence
intervals for differences in responsiveness estimates were derived by bootstrap estimation. Scores derived by these instruments
were interpreted by generalized estimating equation (GEE) before and after cholecystectomy.
Results The examined population significantly (p < 0.05) improved in both SF-36 subscales and GIQLI subscales. After adjusting for time effects (time, and time2) and baseline predictors, GEE approaches revealed the following explanatory variables for QOL: time, time2, age, gender, preoperative GIQLI score, body mass index, and number of comorbidities.
Conclusion The data revealed dramatically improved post-cholecystectomy QOL. However, QOL change was simultaneously associated with preoperative
functional status and demographic characteristics. |
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Keywords: | SF-36 GIQLI Cholecystectomy Bootstrapping GEE |
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