山莨菪碱对梗阻性黄疸心脏的保护作用

目的 观察梗阻性黄疸时山莨菪碱对心脏的保护作用。方法将30只成年Wistar大鼠随机分为假手术组和梗阻性黄疸模型组;模型组包括山莨菪碱治疗组,生理盐水对照组。分别于术后第14、28天测定各组血浆内毒素含量,观察心肌病理、酶组织化学和心率改变及山莨菪碱治疗后的变化。结果生理盐水对照组血浆内毒素水平明显升高,心肌出现变性、局灶坏死、线粒体破损等病理改变,心肌组织琥珀酸脱氢酶、腺苷三磷酸酶活性明显降低(P<0.05),而酸性磷酸酶活性明显增强(P<0.05),心率明显减缓(P<0.05),山莨菪碱治疗组则以上情况均有明显改善(P>0.05)。结论 山莨菪碱对梗阻性黄疸时心脏有保护作用。

Protective effects of anisodamine on heart of obstructive jaundice

Objective To study the protective effects of anisodamine on heart of obstructive jaundice. Methods Thirty adult Wistar rats were randomly divided into three groups: sham operation group (group SO), common bile duct ligation (CBDL) rats injected by anisodamine (group Ani) and CBDL rats injected by normal saline (group NS). Endotoxic plasma levels and heart rate of all groups on the postoperative day 14 and 28 were measured, simultaneously. Myocardial pathologic and enzyme histochemical changes and protective effects of anisodamine were observed. Results Compared with group SO, rats of group NS had obviously higher endotoxic plasma level, lower heart rate and conspicuous pathologic changes in myocardium, such as myocardial degeneration, local necrosis and mitochondrion disruption etc. Furthermore,succinic dehydrogenase (SDH) and adenosine triphosphatase (ATPase) activities of myocardium were decreased, while acid phosphatase (ACP) activities were increased. Compared with group NS, the above conditions were improved significantly in group Ani. Conclusion Anisodamine had protective effects on jaundiced heart which caused by myocardial damage.