| GM-1PLGA肌注微球的制备及其体外释药评价 |
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| 引用本文： | 姜庆城,刘莉,魏欣. GM-1PLGA肌注微球的制备及其体外释药评价[J]. 中国药事, 2011, 0(9): 887-890 |
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| 作者姓名： | 姜庆城 刘莉 魏欣 |
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| 作者单位： | (山东省郯城县第一人民医院,郯城276100) |
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| 摘 要： | 目的 研究以聚乳酸羟基乙酸共聚物为囊材,制备长效缓释的单唾液酸四己糖神经节苷脂微球制剂.方法运用复乳溶剂挥发法,考虑多个条件对制备工艺的影响,并采用正交设计对处方进行优化.测定微球的载药量、包封率和释放曲线.结果制备得到的GM-1微球粒径大小均匀,球形致密圆整,微球粒径为(8.2±6.0)μm,载药量和包封率分别为18...
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| 关 键 词： | 单唾液酸四己糖神经节苷脂 乳酸/羟基乙酸共聚物 微球 缓释制剂 |
The Preparation of GM-1 PLGA Microspheres and Evaluation of the Release Properties in vitro |
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| Jiang Qingcheng,Liu Li,Wei Xin. The Preparation of GM-1 PLGA Microspheres and Evaluation of the Release Properties in vitro[J]. Chinese Pharmaceutical Affairs, 2011, 0(9): 887-890 |
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| Authors: | Jiang Qingcheng Liu Li Wei Xin |
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| Affiliation: | Jiang Qingcheng,Liu Li and Wei Xin(The First People's Hospital of Tancheng,Shandong Province,Tancheng 276100) |
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| Abstract: | Objective To prepare monosialoteterahexosyl ganglioside(GM-1) loaded biodegradable sustained release poly(lactic-co-glycolic acid)(PLGA) microspheres.Methods GM-1 loaded PLGA microspheres were prepared by water-in-oil-in-water double emulsification solvent evaporation process,and the formulation was optimized by orthogonal design.The drug-loading,encapsulation efficiency and release characteristics in vitro were determined.Results The obtained GM-1 PLGA microspheres were uniform spheres with mean particle s... |
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| Keywords: | Monosialoteterahexosyl Ganglioside(GM-1) poly(lactic-co-glycolic acid)(PLGA) microspheres sustained release preparations |
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