人乳头瘤病毒DNA阳性的外阴,宫颈组织病理学表现

目的 探讨外阴、宫颈人乳头瘤病毒（ＨＰＶ）感染与局部组织病理学改变的关系，评价组织病理学检查在ＨＰＶ感染诊断中的意义。方法 采用原位杂交和聚合酶链反应（ＰＣＲ）方法，对１１２例外阴、宫颈病变进行了ＨＰＶ６Ｂ／１１、１６、１８型ＤＮＡ检测，并对ＨＰＶ ＤＮＡ阳性的病变进行组织病理诊断。结果 ＨＰＶ ＤＮＡ阳性者８２例，占７３．２１％，８２例中，组织病理诊断为尖锐湿疣者２２例，其余６０例组织病理学均无

HISTOPATHOLOGIC CHARACTERISTIC OF VULVA/CERVIX WITH POSITIVE HUMAN PAPILLOMA VIRUS DNA

Objective To understand the relationship between vulva/cervix and human papilloma virus infection, and evaluate the score of local histopathologic change in diagnosis of HPV infection. Methods HPV DNA of type 6B/11, 16, 18 were detected in vulva/cervical lesions of 112 cases with in situ hybridization and polymerase chain reaction. The tissues containing HPV DNA were investigated with histopathologic method. Results 82 of 112(73.21%) were positive for HPV DNA. Of 82 cases, 22 patients were diagnosed as condyloma acuminatum, others, cervical glandular erosion, metaplasia, intraepithelial neoplasia vulval/cervical squamous cell cancer, as well as normal tissue. Conclusions HPV infection relates not only to condyloma acuminatum, but also to other cervical lesion. Therefore, routine histopathologic examination and detection of HPV DNA should be simultaneously performed on vulval/cervical tissue.