| 听源性惊厥易感性大鼠在惊厥发作后上丘神经元内c—fos的表达 |
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| 引用本文： | 高殿帅 沈丽. 听源性惊厥易感性大鼠在惊厥发作后上丘神经元内c—fos的表达[J]. 徐州医学院学报, 1999, 19(3): 173-176 |
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| 作者姓名： | 高殿帅 沈丽 |
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| 作者单位： | [1]徐州医学院解剖学教研室 [2]北京医科大学解剖学系 |
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| 摘 要： | 目的 观察听源性惊厥易感性大鼠惊厥发作时上丘内ＦＯＳ免疫阳性神经元的分布。方法 实验动物分４组。ＰＳ组：电铃（１０６ｄＢ，１０－２０ｋＨｚ，６０ｓ）刺激下呈急性惊厥发作的惊厥鼠；ＰＮ组：非急性惊厥发作的惊厥鼠；ＷＳ组：电铃刺激的正常鼠：ＷＮ组；无电铃刺激的正常鼠，每组各５只，ＰＳ和ＷＳ组电铃刺激后存活２ｈ。结果 （１）只有在ＰＳ大鼠的上丘可见有典型的ＦＯＳ样免疫阳性神经元，且其只分布在第Ⅳ，Ⅵ，Ⅶ
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| 关 键 词： | 听源性惊厥 上丘 惊厥 c－fos基因 大鼠 |
EXPRESSION OF c-fos OF THE NEURONS IN THE SUPERIOR COLLICULUS OF THEAUDIOGENIC SEIZURES SUSCEPTIBLE REATS(P77PMC) DURING SEIZURES |
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| Gao Dianshuai,Shen Li,Yu Enhua,et al. EXPRESSION OF c-fos OF THE NEURONS IN THE SUPERIOR COLLICULUS OF THEAUDIOGENIC SEIZURES SUSCEPTIBLE REATS(P77PMC) DURING SEIZURES[J]. Acta Academiae Medicinae Xuzhou, 1999, 19(3): 173-176 |
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| Authors: | Gao Dianshuai Shen Li Yu Enhua et al |
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| Abstract: | Objective To identity the neuronal populations with the expression of c-fos in the superior colliculus of the audiogenic seizures susceptible rats during seizures. Methods The experimental animals were divided into 4 groups. PS: the P77PMC rats, submittes to the acoustic stimuli delivered by an electric generator (106 dB, 1020 kHz, 60 s), exhibiting typical audiogenic seizures; PN: the P77PMC rats with neither sound stimuli nor seizures; WS: the non epilepric normal control Wistar rats, exposed to the same auditory stimuli; WN: normal control Wistar rats, with no auditory stimulation . The animals of PS and WS were allowed to survive for 2 h after stimulation, and then all the animals were subjected to the assessment of c-fos expression by immunocytochemistry. Results It was only in the PS rats that exhibited typical FOS-like immunoreactivity(FL-) positive neurons in the superior colliculus, and the FL- positive neurons were found only in layer ,layer and layer . The positive neurons in these |
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| Keywords: | Audiogenic seizureSuperior colliculusProtooncogenec-foslayers were more crowded in the caudal segment of the superior colliculus. Conclusion The fit of audiogenic seizures is associated with the increased c-fos gene expression in particular subsets of neu |
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