兔半侧颜面移植模型

目的 为异体颜面移植（换脸）的研究建立一种动物模型.方法 以青紫蓝兔及新西兰大白兔为实验动物,应用颈外动脉携带其分支颌外动脉和耳大动脉为蒂,获得半侧颜面游离复合组织瓣,进行同种异体移植,其中青紫蓝兔为受体、新西兰大白兔为供体.术后观测复合组织瓣的存活情况,检验实验动物模型的可行性.结果 通过美蓝显示应用本程序获得的游离复合组织瓣模型,依靠颈外动脉供血,可以保证其存活.结论 本实验程序可以作为研究异体颜面移植的一种良好模型.

A hemifacial transplantation model in hares

ObjectiveTo design an animal model to study the facial transplantation of allografts in rabbits. Methods Livid blue rabbits and New Zealand white rabbits was applied as experiment animal,to harvest hemifacial composite-tissue flap based in the common external carotid artery with the branch of the external mandibular artery and auricularis magna artery,then allotransplantation was performed with the livid blue rabbits as recipient while new Zealand rabbits as donor, the immunosuppressive agent comprised ciclosporin, azamun and prednisone. 25 couples of rabbits were divided three groups. Group A,5 couples of rabbits, no administered immunosuppressive agent and the artery anastomosis with end-to-end. Group B, 10 couples of rabbits, administered immunosuppressive agent and the artery anastomosis with end-to-end. Group C,10 couples of rabbits, administered immunosuppressive agent and the artery anastomosis with end-to-side.Postoperative,to observe the survive ratio of animal and composite-tissue flap, verified the practicability of model further. Results The blood supply of hemifacial composite-tissue flap is rich after allotransplantation. The survive ratio wasn't different with different procedure of the external carotid artery anastomosis. ConclusionsThis is a successful model of composite face flap transplantation in the rabbits.