基质金属蛋白酶-9与急性缺血性脑卒中的相关性研究

目的 通过检测急性缺血性脑卒中患者血浆基质金属蛋白酶-9( matrix metalloproteinase-9,MMP-9)水平变化,探讨其在急性缺血性脑卒中发生发展过程中的作用和意义.方法 选择急性缺血性脑卒中患者162例为研究对象,未卒中患者100例作对照,血浆MMP-9检测采用酶联免疫法.结果 (1)急性缺血性...

Association of matrix metalloproteinases-9 with acute ischemic stroke

Objective To explore the role and significance of plasma matrix metalloproteinases9 ( MMP-9 )in the genesis and development of acute ischemic stroke by detecting the changes of MMP9 in the patients.Methods 162 patients with acute ischemic stroke were enrolled as research subjects and 100 patients were used as a control.Plasma MMP-9 levels were detected by ELISA.Results MMP-9 level was significantly higher in the stroke group than in the control group ( 193.0 ± 29.3 )μg/L vs.( 82.5 ± 13.7 ) μ g/L,P＜ 0.05].MMP-9 concentration was positively correlated with the risk of acute ischemic stroke.MMP-9 level did not differ significantly among the subtypes of acute ischemic stroke ( 188.3 ± 23.9 ) μ g/L in LAA,( 197.5 ± 30.2 ) μ ug/L in CE,( 191.2 ± 32.8 ) μ g/L in SAA,( 190.0 ± 0.0 ) μ g/L in SOE,and ( 200.0 ± 23.5 ) μ g/L in SUE; P ＞ 0.05].Conclusions MMP-9 is a risk marker of acute ischemic stroke.MMP-9 determination is beneficial in the guidance of prevention strategy for acute ischaemic stroke and provides support for clinical treatment.