粪便隐血免疫双联法在服用小剂量肠溶阿司匹林致消化道出血中的应用研究

目的 探讨粪便隐血免疫双联法在监测服用小剂量肠溶阿司匹林(ASA)致消化道出血中的应用价值.方法 对328例需长期服用小剂量ASA的患者和对照组30例,要求不服用口服抗凝剂、无消化道出血征象的心脑血管疾病患者,分别于服药前、服用1周、1个月、3个月、6个月应用隐血免疫双联法(血红蛋白免疫法和转铁蛋白免疫法)检测粪便隐血...

To investigate the application of dejecta occult blood with hemoglobin and/or transferrin monoclonal immunoassay on gastrointestinal bleeding induced by taking low-dose ASA

Objective To explore the application value of dejecta occult blood coupled with hemoglobin and/or transferrin monoclonal immunoassay on inspect gastrointestinal bleeding induced by taking low-dose ASA.Methods 328 cases taking low-dose ASA in long-time were set as therapy group;30 cases patients with Heart-Brain vas disease not taking ASA and not having the sign of gastrointestinal bleeding were set as control group,Detected dejecta occult blood with hemoglobin and/or transferrin monoclonal immunoassay 1 week,1 month,3 months,6 months before taking medicine.Took Gastroscopy if dejecta occult blood were positive to see if upper gastrointestinal were bleeding or not.Results ① Among these 328 patients,dejecta occult blood was detected with hemoglobin and/or transferrin monoclonal immunoassay; 40 cases were positive( 12.2％ )in therapy group,while control group had 1 case(3.3％,1/30);there was statistical difference ( P ＜ 0.05 ).② There were 29 cases taking Gastroscopy of 40 cases whose dejecta occult blood was positive; 24 cases had pathology significance; hemoglobin and transferrin monoclonal immunoassay was positive of the other 5 cases.③There was no statistical significant difference on bleeding time (P＞ 0.05 ).Conclusion Dejecta occult blood detected with hemoglobin and/or transferrin monoclonal immunoassay could be a routine inspection for gastrointestinal bleeding induced by taking low-dose ASA in long-time.