| Serum resistin and adiponectin concentrations in patients with overweight and obesity |
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| 作者姓名： | References： |
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| 作者单位： | [1]Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Department of Physiology and Pathophysiology, Medical College of Xi＇an Jiaotong University, Xi＇an 710061, China [2]Department of Cardiovascular Medicine, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China |
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| 摘 要： | Objective： To explore the serum levels of resistin and adiponectin in patients with overweight and obesity. Methods： Fifty-eight cases with normal weight and 24 patients with overweight and obesity have taken fasting blood samples for measurements of plasma glucose, plasma lipids, insulin, C-peptide, thyroid hormones, C-response protein, interleukin-6, TNF-α, leptin, adiponectin and resistin. Results： The concentrations of resistin in cases with overweight and obesity were significant higher than those in the normal weight cases （16. 01 ± 8. 60 vs 11. 63 ± 9. 05 ng/ml, P = 0. 047）. Pearson relation analysis showed that serum resistin concentrations were positively correlated with age （r= 0. 476, P = 0.019）, but negatively correlated with C-peptide （r=-0.45, P=0. 024）, and adiponectin concentrations were positively correlated with HDL-c （r=0. 463, P=0. 023） and systolic blood pressure （r=0. 409, P=0. 047） in overweight and obesity cases. Conclusion： The concentrations of resistin in cases with over-weight and obesity are higher, and there is no correlation between resistin and blood glucose, blood lipids and insulin, while the serum adiponectin concentrations positively correlated with HDL-c and systolic blood pressure.
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| 关 键 词： | 肥胖症 免疫血清抵抗素 脂肪 治疗方法 |
| 收稿时间： | 20 January 2007 |
| 修稿时间： | 2007-01-202007-04-20 |
Serum resistin and adiponectin concentrations in patients with overweight and obesity |
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| LUO Rong,LI Xiao-ping,ZHAO Yan.Serum resistin and adiponectin concentrations in patients with overweight and obesity[J].Journal of Medical Colleges of PLA(China),2007,22(3):160-164. |
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| Authors: | LUO Rong LI Xiao-ping ZHAO Yan |
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| Institution: | 1. Department of Medicine and Surgery, Section of Internal and Cardiovascular Medicine, University of Perugia, Perugia, Italy;2. Department of Medicine and Surgery, Division of Anaesthesia, Analgesia, and Intensive Care, University of Perugia, Perugia, Italy;3. Division of Internal Medicine, ASL 1 Umbria, Città di Castello;4. Unit of Internal Medicine, Terni University Hospital, Italy;5. Section of Anesthesia, Intensive Care and Pain Medicine, Department of Emergency and Urgency, Città di Castello Hospital, Città di Castello;6. Section of Anesthesia, Intensive Care, and Pain Medicine, Azienda Ospedaliera-Universitaria Santa Maria della Misericordia, Perugia, Italy;7. Section of Anesthesia and Intensive Care, Presidio Alto Chiascio, USL Umbria 1, Gubbio, Italy;1. Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy;2. First Clinic of Internal Medicine, Department of Internal Medicine, and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy;3. IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascular Network, 10 Largo Benzi, 16132 Genoa, Italy;4. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran;5. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;6. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;1. Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York- Binghamton, NY, USA;2. Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, State University of New York- Binghamton, NY, USA |
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| Abstract: | ObjectiveTo explore the serum levels of resistin and adiponectin in patients with overweight and obesity.MethodsFifty-eight cases with normal weight and 24 patients with overweight and obesity have taken fasting blood samples for measurements of plasma glucose, plasma lipids, insulin, C-peptide, thyroid hormones, C-response protein, interleukin-6, TNF-α, leptin, adiponectin and resistin.ResultsThe concentrations of resistin in cases with overweight and obesity were significant higher than those in the normal weight cases (16.01 ± 8.60 vs 11.63 ± 9.05 ng/ml, P = 0.047). Pearson relation analysis showed that serum resistin concentrations were positively correlated with age (r = 0.476, P = 0.019), but negatively correlated with C-peptide (r = ?0.45, P = 0.024), and adiponectin concentrations were positively correlated with HDL-c (r = 0.463, P = 0.023) and systolic blood pressure (r = 0.409, P = 0.047) in overweight and obesity cases.ConclusionThe concentrations of resistin in cases with over-weight and obesity are higher, and there is no correlation between resistin and blood glucose, blood lipids and insulin, while the serum adiponectin concentrations positively correlated with HDL-c and systolic blood pressure. |
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| Keywords: | resistin adiponectin overweight and obesity |
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