雷公藤多苷联合黄葵胶囊治疗糖尿病肾病临床疗效及对炎症因子的影响

目的:探讨双倍剂量雷公藤多苷联合黄葵胶囊治疗糖尿病肾病(DN)的临床疗效及炎症因子水平。方法:将126例DN患者分为对照组(单用黄葵胶囊)和观察组(黄葵胶囊联合双倍剂量雷公藤多苷片),8周为1疗程。治疗前后分别检测血清炎症指标[白细胞介素(IL)~(-1)8,IL-6,超敏C-反应蛋白(Hs-CRP)]及肝肾功能,24 h尿蛋白定量等。结果:观察组总有效率明显优于对照组(P0.05)。两组患者治疗后尿蛋白明显减少,肾功能改善,血浆白蛋白升高,IL~(-1)8,Hs-CRP,IL-6显著降低(P0.01)。观察组各项指标均优于对照组(P0.01)。未见肝功能损害。结论:双倍剂量雷公藤多苷联合黄葵胶囊可降低血清炎症指标,提高DN的临床疗效。

Efficacy of Glucosidorum Tripterygll Totorum Combined with Ambrette Capsules in Treatment of Diabetic Nephropathy and Its Effect on Inflammatory Factors

Objective: To investigate the clinical efficacy of double dose glucosidorum tripterygll totorum combined with ambrette capsule in the treatment of diabetic nephropathy (DN) and observe its effect on the level of inflammatory factors. Method: The 126 patients with DN were divided into control group (with ambrette capsules alone) and observation group (double dose glucosidorum tripterygll totorum combined with ambrette capsules). 8 weeks were regarded as one course of treatment. Before and after the treatment, the inflammatory indexes in serum[interleukin (IL)-18, IL-6, hypersensitive C-reactive protein(Hs-CRP)], liver and kidney function, 24 h urinary protein. Result: The total effective rate in the observation group was significantly higher than that in the control group, with significant difference between two groups(P<0.05). After treatment, urinary protein was significantly decreased, renal function improved, plasma albumin increased, Hs-CRP, IL-18 and IL-6 significantly decreased in both groups (P<0.01). The observation group was significantly better than the control group in the comparison of above indexes (P<0.01). No liver function damage was seen. Conclusion: Double dose glucosidorum tripterygll totorum combined with ambrette capsules can reduce the inflammation indexes in serum, and improve the clinical efficacy of DN.