尼尔雌醇对去卵巢大鼠子宫内膜的影响

目的观察西药尼尔雌醇对去卵巢大鼠子宫内膜的影响。方法选择36只7月龄SD大鼠，12只为假手术组，24只为造模组。造模组行双侧卵巢摘除术，假手术组仅切除一段肠系膜。去卵巢后60d，将造模组大鼠随机分为2组，尼尔雌醇组用尼尔雌醇液灌胃，假手术组与模型组均用生理盐水灌胃，60d后处死动物，常规切片，染色，光镜观察，摄片。结果模型组8只大鼠子宫内膜呈增生或萎缩型改变。假手术组5只大鼠呈增生期改变，3只呈分泌期改变。尼尔雌醇组8只大鼠子宫内膜均呈分泌期改变。结论尼尔雌醇可使去卵巢大鼠子宫内膜发生分泌期改变，这一实验结果有悖于目前的内分泌学说，亦不同于既往的实验报道。

The Influence of Nilestriol on Endometrium in Ovariectomized Rats

Objective To investigate the influence of nilestriol on endometria of ovariectomized rats. Methods Thirty-six female 7-month old Sprague-Dawley rats were divided randomly into sham-operation group(12 rats) and model group(24 rats).Bilateral ovariectomy was performed on the rats of model group.The rats of sham-operation group were only sham operated.Two months after operation the model group was divided randomly into two subgroups: model group and nilestriol group.Nilestriol group was treated with nilestriol;model group and sham-operation group received saline.After two months of the treatment all rats were killed and the endometria were removed and processed for histopathological examination.Result In model group(8 rats) the endometria were of proliferative phase or atrophy phase.In sham-operation group the ecndometria were of proliferative phase(5 rats) and secretory phase(3 rats).In nilestriol group all of the endometria were of secretory phase(8 rats).Conclusion Nilestriol can induce a secretory phase endometria in ovariectomized rats.Because those results are in apparent contrary to the current endocrinology theory and are different from the reports of previous animal experiments,we decided to make this report and believe it deserves further studies.