MR imaging in adults with Gaucher disease type I: evaluation of marrow involvement and disease activity |
| |
Authors: | George Hermann M.D. Robert S. Shapiro M.D. I. Fikry Abdelwahab M.D. Gregory Grabowski M.D. |
| |
Affiliation: | (1) Department of Radiology, Mount Sinai Medical Center, City University of New York, New York, USA;(2) Department of Pediatrics, Mount Sinai Medical Center, City University of New York, New York, USA;(3) Mount Sinai Medical Center, One Gustave L. Levy Place, Box 1234, 10029-6574 New York, NY, USA |
| |
Abstract: | An investigation was conducted to determine the usefulness of magnetic resonance imaging (MRI) in the evaluation of bone marrow involvement in patients with Gaucher disease type I. T1- and T2-weighted images were obtained of the lower extremities of 29 adult patients. Patients were classified into one of three groups based on marrow signal patterns on T1- and T2-weighted images as well as change in signal intensity from T1- to T2-weighted images. An increase in signal intensity from T1- to T2-weighted images was the criterion for an active process within the bone marrow. Classification of the 29 patients produced the following results: group A: normal, 4 patients; group B: marrow infiltration, 16 patients; group C: marrow infiltration plus active marrow process, 9 patients. Correlation with clinical findings revealed that all nine patients with evidence of an active marrow process on MRI (group C) had acute bone pain. Conversely, only one of the remaining 20 patients (groups A and B) had bone pain. There was no correlation between disease activity and findings on conventional radiographs. We conclude the MRI provides an excellent noninvasive assessment of the extent and activity of marrow involvement in type I Gaucher disease. |
| |
Keywords: | Gaucher disease Magnetic resonance imaging Bone marrow |
本文献已被 SpringerLink 等数据库收录! |
|