| 碱性成纤维细胞生长因子/胶原膜修复大鼠硬腭软组织缺损的实验研究 |
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| 引用本文： | 刘双喜,徐淑兰,钟星华,周敏,杨烁.碱性成纤维细胞生长因子/胶原膜修复大鼠硬腭软组织缺损的实验研究[J].广东医学,2011,32(11). |
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| 作者姓名： | 刘双喜 徐淑兰 钟星华 周敏 杨烁 |
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| 作者单位： | 南方医科大学附属口腔医院、广东省口腔医院种植中心,广州,510280 |
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| 基金项目： | 广东省医学科学技术研究基金立项项目 |
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| 摘 要： | 目的 利用与碱性成纤维细胞生长因子(bFGF)特异结合的胶原膜修复大鼠硬腭软组织缺损,观察其对大鼠创面修复的影响.方法 48只6周龄雄性Wistar大鼠随机分成4组,每只大鼠硬腭第一磨牙近中至第三磨牙远中的软组织作一直径为3 mm的圆形缺损,分别植入结合bFGF/胶原膜、游离bFGF/胶原膜、胶原膜及不植入任何修复块(空白对照组).每组大鼠分别在术后1、2周处死6只,HE染色测上皮组织间距离,比较创面愈合率.结果 1周时创面愈合率差异有统计学意义,结合bFGF/胶原膜组>游离bFGF/胶原膜组≈胶原膜组>空白对照组;2周时创面愈合率差异无统计学意义.结论 结合bFGF/胶原膜能加快大鼠硬腭软组织的修复.
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| 关 键 词： | 碱性成纤维细胞生长因子 胶原膜 软组织缺损 创面愈合率 |
Effect of collagen-targeting basic fibroblast growth factor loaded collagen membrane on soft tissue repairmen of rat hard palate |
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| LIU Shuang-xi,XU Shu-lan,ZHONG Xing-hua,ZHOU Min,YANG Shou.Effect of collagen-targeting basic fibroblast growth factor loaded collagen membrane on soft tissue repairmen of rat hard palate[J].Guangdong Medical Journal,2011,32(11). |
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| Authors: | LIU Shuang-xi XU Shu-lan ZHONG Xing-hua ZHOU Min YANG Shou |
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| Abstract: | Objective To evaluate the effects of collagen-binding basic fibroblast growth factor(bFGF) loaded collagen membrane on soft tissue repairmen of rat hard palate.Methods Forty-eight male Wistar rats of 6-week-old were randomly divided into 4 groups.A 3 mm diameter circular soft tissue defect was produced in the center of hard palate of rats.The defects were covered with collagen-targeting bFGF/collagen membrane,free bFGF/collagen membrane,collagen membrane and no membrane(control group) in different groups.Ea... |
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| Keywords: | basic fibroblast growth factor collagen membrane soft tissue defect the degree of re-epithelialization |
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