A chitosan-modified graphene nanogel for noninvasive controlled drug release |
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| Authors: | Chunyan Wang Jaya Mallela Ujjwala Sree Garapati Sowndharya Ravi Vignesh Chinnasamy Yvonne Girard Mark Howell Subhra Mohapatra |
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| Institution: | 1. Molecular Medicine Department, Morsani College of Medicine, University of South Florida, Tampa, FL, USA;2. USF Nanomedicine Research Center, Morsani College of Medicine, University of South Florida, Tampa, FL, USA |
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| Abstract: | A near infrared (NIR) triggered drug delivery platform based on the chitosan-modified chemically reduced graphene oxide (CRGO) incorporated into a thermosensitive nanogel (CGN) was developed. CGN exhibited an NIR-induced thermal effect similar to that of CRGO, reversible thermo-responsive characteristics at 37-42 °C and high doxorubicin hydrochloride (DOX) loading capacity (48 wt%). The DOX loaded CGN (DOX-CGN) released DOX faster at 42 °C than at 37 °C. The fluorescence images revealed DOX expression in the cytoplasm of cancer cells when incubated with DOX-CGN at 37 °C but in the nucleus at 42 °C. Upon irradiation with NIR light (808 nm), a rapid, repetitive DOX release from the DOX-CGN was observed. Furthermore, the cancer cells incubated with DOX-CGN and irradiated with NIR light displayed significantly greater cytotoxicity than without irradiation owing to NIR-triggered increase in temperature leading to nuclear DOX release. These results demonstrate CGN's promising application for on-demand drug release by NIR light.From the Clinical EditorThese investigators report the successful development of a novel near infrared triggered drug delivery platform based on chitosan-modified chemically reduced graphene oxide (CRGO) incorporated into a thermosensitive nanogel (CGN). |
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