| 复方熊胆制剂抗疲劳作用研究 |
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| 引用本文： | 翟凤国,晁岳刚,杨世杰.复方熊胆制剂抗疲劳作用研究[J].中国基层医药,2010,17(24):3342-3344. |
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| 作者姓名： | 翟凤国 晁岳刚 杨世杰 |
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| 作者单位： | [1]牡丹江医学院药理教研室,黑龙江省牡丹江157011 [2]牡丹江医学院基础医学部,黑龙江省牡丹江157011 [3]吉林大学基础医学院药理教研室,黑龙江省牡丹江157011 |
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| 摘 要： | 目的 探讨复方熊胆制剂的抗疲劳作用,为临床用药提供可靠的实验室依据.方法 以小鼠为实验对象,给予不同剂量的复方熊胆制剂灌胃饲养,观察复方熊胆制剂对小鼠游泳时间、爬杆时间及游泳后肝糖元、血清尿素氮、血乳酸、乳酸脱氢酶等生化指标.结果 复方熊胆制剂能明显延长小鼠负重游泳时间和爬杆时间,提高小鼠运动后肝糖元含量和血乳酸脱氢酶活力,降低血清尿素氮和血乳酸含量.结论 复方熊胆制剂具有抗疲劳作用.
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| 关 键 词： | 复方熊胆制剂 抗疲劳 肝糖原 乳酸 乳酸脱氢酶 |
The Anti-fatigue Effect of Complex Bear Gall Agent in Mice |
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| ZHAI Feng-guo,CHAO Yue-gang,YANG Shi-jie.The Anti-fatigue Effect of Complex Bear Gall Agent in Mice[J].Chinese Journal of Primary Medicine and Pharmacy,2010,17(24):3342-3344. |
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| Authors: | ZHAI Feng-guo CHAO Yue-gang YANG Shi-jie |
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| Institution: | 1.Department of Pharmacology,Mudanjiang Medical College,Mudanjiang,Heilongjiang 157011 ,China;) |
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| Abstract: | Objective To investigate the anti-fatigue effect of complex bear gall agent in mice.Methods Different dose of complex bear gall agent(4.4ml/kg、6.6ml/kg、13.2rml/kg)were given to mice by intragastric administration. The time of climbing-pole and loaded-swimming, hepatic glycogen content, serum urea nitrogen,lactic acid and lactate dehydrogenase of mice after swim were observed. Results The experiments indicated that complex bear gall agent could greatly increase the time of loaded-swimming and climbing Pole,increase the hepatic glycogen content and serum lactate dehydrogenase activity ,decrease serum urea nitrogen and blood lactic acid content in mice. Conclusion Complex bear gall agent had a significant anti-fatigue effect. |
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| Keywords: | Complex bear gall agent Anti-fatigue Hepatic glycogen Lactic acid Lactate dehydrogenase |
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