应用SPECT观察激光血管内照射对2型糖尿病早期肾病患者肾功能的影响

目的　研究低强度激光血管内照射 (ILIB)对 2型糖尿病早期肾病患者肾功能的影响。方法　共选取 15例糖尿病早期肾病患者 ,在其常规治疗的基础上加用ILIB ,所有患者分别于ILIB治疗前、后给予同位素 99mTc EC肾功能显像检查 ,并观察其肾组织高峰到达时间 (Tmax)、10min残留率及 15min残留率等指标的变化情况。结果　本研究患者经ILIB治疗后 ,其 10min残留率明显减少 (左、右肾均P <0 .0 5或 0 .0 1) ,15min残留率亦显著降低 (左、右肾均P <0 .0 5 ) ,而患者的Tmax治疗前、后差异无显著性意义 (左、右肾均P >0 .0 5 )。结论　ILIB治疗能显著改善 2型糖尿病早期肾病患者肾小管的分泌及排泄功能 ,可作为糖尿病早期肾病患者的有效治疗手段之一。

The effect of intravascular low energy laser irradiation on renal function of patients with early diabetic nephropathy as revealed by the SPECT

Objective To investigate the effects of intravascular low energy laser irradiation on blood (ILIB) on renal function of the patients with early diabetic nephropathy. Methods Fifteen patients with type 2 diabetes mellitus complicated with early diabetic nephropathy, were treated with ILIB in addition to the conventional drugs, and observed the maximal time(Tmax)of renal concentration,the variation of 10 minutes residual rate and 15 minutes residual rate, respectively, by using the SPECT of isotone 99mTc-EC before and after ILIB treatment, and compared the results obtained before and after ILIB treatment. Results There were significant differences with regard to the 10 minutes residual rate (both the left and right kidney,P<0.05 or 0.01) and the 15 minutes residual rate (both the left and right kidney, P<0.05) when comparison was made before and after ILIB treatment, with all the parameters obviously declined after the ILIB treatment, but there was no significant difference with regard to the maximal time of renal concentration (both the left and right kidney, P>0.05). Conclusion ILIB could improve the excretion and secretion function of renal tubule in patients with the type 2 diabetes mellitus complicated with early diabetic nephropathy, and ILIB could be used as an effectively therapeutic method for patients with early diabetic nephropathy.