A light- and electron-microscopic study of GluR4-positive cells in cerebral cortex,subcortical white matter and corpus callosum of neonatal,immature and adult rats |
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Authors: | W Y Ong S K Leong L J Garey R Reynolds |
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Institution: | (1) Department of Anatomy, National University of Singapore, 119260, Singapore;(2) Department of Anatomy, Charing Cross and Westminster Medical School, W6 8RF London, UK |
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Abstract: | The distribution of the 3H]alpha-amino-3-hydroxy-5-methylisoxzalepropionic acid (AMPA) receptor subunit GluR4 was studied in frontal, parietal and temporal cerebral cortex, subcortical white matter and corpus callosum of neonatal, immature and mature rats. In 1-to 2-day-old rats, a few oligodendrocyte progenitors and amoeboid microglia in the supraventricular part of the corpus callosum were immunolabelled for GluR4. At 7 to 10 days, the number of amoeboid microglia and oligodendrocyte progenitors in white matter increased; many neurons in cortex, including pyramidal neurons, were also moderately labelled for GluR4. The pattern of GluR4 immunostaining in 14-day-old rats was different from that in 7-to 10-day-old rats, but similar to the adult, in that there was no immunoreactivity in microglia and oligodendrocyte progenitors in subcortical white matter. A proportion of non-pyramidal neurons in cortex were moderately labelled, while some pyramidal neurons were lightly labelled. A population of small glial cells with features of oligodendrocyte progenitors were densely labelled in cortex. |
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Keywords: | Glutamate receptor Cerebral cortex White matter Electron microscopy Development Rat |
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