妊娠中期引产228例临床效果分析

目的:探讨米非司酮配伍米索前列醇用于妊娠中期引产的临床效果.方法:对2008年1月～2010年12月来我院就诊妊娠12～24周要求引产者228例,按不同引产方式进行分组,药物组(140例)及利凡诺组(88例),对两组引产效果进行分析.药物组根据米索前列醇不同给药方式分为口服组及直肠给药组,比较引产时间及用药剂量.结果:药物组与利凡诺组胎盘胎膜残留、引产时间及出血量比较差异有显著性(P＜0.05)；妊娠12～16周,口服组与直肠给药组引产时间比较差异有显著性(P＜0.05)；妊娠16～24周,口服组与直肠给药组米索前列醇用量比较差异有显著性(P＜0.05).结论:米非司酮配伍米索前列醇用于中期引产具有成功率高、完全流产率高、引产时间短及阴道流血量少等优点,根据孕周不同,选择合适米索前列醇的给药方式可提高引产效率,减轻患者痛苦.

Effective analysis on medium-term induction of labor in 228 cases

Objective：To investigate the clinical effects of mifepristone and misoprostol on medium-term induction of labor.Methods：228 cases of pregnancy with 12～24 weeks and requiring induction of labor in our hospital from January 2008 to December 2010 were grouped according to different induction modes,the medicinal group（140 cases） and the acrinol group（88 cases）.The effects of induction of labor were analyzed.The medicinal group was redivided into the oral group and rectal administration group according to different administrations of misoprostol.The time of induction of labor and drug dosages were compared between these two groups.Results：There were significant difference in placenta and membrane residues,abortion time and amount of bleeding between the medicinal group and the acrinol group.The abortion time for 12～16 weeks pregnancy in the oral group was shorter than that in the rectal administration group.The dosages of misoprostol for 16～24 weeks pregnancy revealed significant difference between the oral group and the rectal administration group.Conclusion：Application of mifepristone and misoprostol in medium-term induction of labor has many advantages of the high success rate,high rate of complete abortion,short time of abortion and less vaginal bleeding.According to different gestational weeks,selecting the appropriate administration mode of misoprostol can increase the efficiency of labor induction and reduce patient′s suffering.