| 氟伐他汀对原发性高血压患者心脏肥厚及舒张功能的影响 |
| |
| 引用本文： | 肖霖,王建平,张国辉,汪建飞.氟伐他汀对原发性高血压患者心脏肥厚及舒张功能的影响[J].现代医药卫生,2011,27(14):2081-2083. |
| |
| 作者姓名： | 肖霖 王建平 张国辉 汪建飞 |
| |
| 作者单位： | 江苏大学附属人民医院心内科,江苏镇江,212002 |
| |
| 摘 要： | 目的:探讨他汀类药物能否改善原发性高血压患者的左心室肥厚(left ventricular hypertrophy,LVH)及心脏舒张功能.方法:对110例血脂正常或轻度升高的原发性高血压患者采用随机、单盲、对照研究.用非洛地平降压同时分别加用氟伐他汀或安慰剂治疗24周.于治疗前、后检测室间隔厚度(IVS)、左心室后壁厚度(LVPW)、左心室舒张末期内径(LVDd),计算出左心室质量(LVM)及心肌重量指数(LVMI);测量及记录舒张早期及舒张晚期最大速度.检测血浆I型前胶原羧基端肽(PIP)及脑钠肽(BNP).结果:联合治疗组较安慰剂组血压达标率增加,脉压减小,24周后血浆PIP及BNP水平降低,LVMH、LVMI显著降低(P＜0.05);同安慰剂组相比,联合治疗组24周后二尖瓣后叶瓣环与左室侧壁交界处舒张早期及舒张晚期最大速度之比增加(P＜0.05).结论:高血压患者加用氟伐他汀可使心肌纤维化的相关指标改善、血压降低,逆转左心室肥厚及改善心脏舒张功能.
|
| 关 键 词： | 高血压 左心室肥厚 左室功能 氟伐他汀 |
Effect of fluvastatin on ventricular hypertrophy and diastolic function in essential hypertension |
| |
| XIAO Lin
,
WANG Jian-ping
,
ZHANG Guo-hui
,
WANG Jian-fei.Effect of fluvastatin on ventricular hypertrophy and diastolic function in essential hypertension[J].Modern Medicine Health,2011,27(14):2081-2083. |
| |
| Authors: | XIAO Lin WANG Jian-ping ZHANG Guo-hui WANG Jian-fei |
| |
| Institution: | (Department of Cardiology,Affiliated People′ s Hospital,Jiangsu University,Zhenjiang,Jiangsu 212002,China) |
| |
| Abstract: | Objective:To investigate whether statins have the improvement effects on the left ventricular hypertrophy(LVH) and diastolic function of both left and right ventricles in essential hypertension(EH) patients.Methods:The randomized,mono-blind,placebo controlled study was adopted.110 EH patients with normal or slightly elevated cholesterol randomly took placebo or fluvatain(40 mg once per night) for 24 weeks.Felodipine tablets were given to EH patients.The left ventricular posterior wall thickness(LVPW),the le... |
| |
| Keywords: | Hypertension Left ventricular hypertrophy Left ventricular function Fluvatain |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
