| P38与JNK在肾透明细胞癌中的表达及其临床意义 |
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| 引用本文： | 杜昌国,王健,孙茂坤,李鹏.P38与JNK在肾透明细胞癌中的表达及其临床意义[J].现代医药卫生,2011,27(16):2405-2407. |
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| 作者姓名： | 杜昌国 王健 孙茂坤 李鹏 |
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| 作者单位： | 1. 青海大学医学院,青海西宁,810001
2. 青海大学附属医院,青海西宁,810001 |
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| 摘 要： | 目的:探讨在肾透明细胞癌中丝裂原活化蛋白激酶P38(p38MAPK,p38)和c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)的表达及其临床意义.方法:采用免疫组织化学方法,研究癌旁正常组织(20例)、肾透明细胞癌组织(52例)中P38和JNK蛋白的表达情况.结果:P38和JNK在肾透明细胞癌中的阳性表达率分别为75.00％和63.49％,而在癌旁正常组织中阳性表达率分别为30.00％和25.00％.P38和JNK在肾透明细胞癌中的阳性表达率明显高于癌旁正常组织(P＜0.01和P＜0.05),与肿瘤的临床TNM分期、病理分化相关(P＜0.05),而与患者性别、年龄无关(P＞0.05).对肾透明细胞癌中P38和JNK进行相关性分析呈正相关(r＝0.484,P＜0.001).结论:在肾透明细胞癌中P38和JNK的表达高于癌旁组织,且与肿瘤的临床TNM分期、病理分化相关,提示P38和JNK与肾组织癌变、侵袭和转移过程有关.
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| 关 键 词： | 肾透明细胞癌 P38 JNK 免疫组织化学 |
Expressions and clinical significance of P38 and JNK in renal clear cell carcinoma |
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| DU Chang-guo
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WANG Jian
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SUN Mao-kun
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LI Peng.Expressions and clinical significance of P38 and JNK in renal clear cell carcinoma[J].Modern Medicine Health,2011,27(16):2405-2407. |
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| Authors: | DU Chang-guo WANG Jian SUN Mao-kun LI Peng |
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| Institution: | DU Chang-guo1,WANG Jian2,SUN Mao-kun1,LI Peng1(1.Medical College,Qinghai University,Xining,Qinghai 810001,China,2.Affiliated Hospital,China) |
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| Abstract: | Objective:To explore the expressions and clinical significance of P38 and JNK in renal clear cell carcinoma(RCCC).Methods:The immunohistochemical method was performed to detect expression of p38 and JNK in 52 cases of RCCC and 20 cases of normal renal tissues closely adjacent to carcinoma.Results:The positive expression rate of p38 was 75.00% in RCCC and 30.00% in normal renal tissues closely adjacent to carcinoma.The positive expression rate of JNK was 63.49% in RCCC and 25.00% in normal renal tissues clos... |
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| Keywords: | Renal clear cell carcinoma P38 JNK Immunohistochemistry |
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