醛固酮与顽固性高血压

顽固性高血压是指同时服用包含利尿剂在内的3种不同作用机制的降压药物后,血压仍在目标水平之上,是一种特殊类型的高血压,临床并不少见。醛固酮是人体内最重要、作用最强的盐皮质激素,广泛参与体内各种代谢活动,醛固酮的过多分泌在顽固性高血压的发生发展中起着重要作用。

Aldosterone and resistant hypertension

Resistant hypertension is defined as blood pressure that remains above goal despite the use of three different antihypertensive medications in effective doses, ideally including a diuretic. It is special and not rare in clinic. Aldosterone, the most important mineralocorticoid, is extensively involved in various metabolic activities. However, aldosterone excess plays an important role in the development of resistant hypertension.