| 碱性成纤维细胞生长因子在大鼠脊髓损伤后的表达及意义 |
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| 引用本文： | 邓莉,李明. 碱性成纤维细胞生长因子在大鼠脊髓损伤后的表达及意义[J]. 现代医药卫生, 2011, 27(15): 2243-2244 |
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| 作者姓名： | 邓莉 李明 |
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| 作者单位： | 1. 泸州医学院神经生物研究室，四川泸州,646000
2. 昆明医学院解剖教研室，云南昆明,650031 |
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| 摘 要： | 目的:探讨脊髓损伤后的自我保护修复机制.方法:采用改良的Allen’s法建立SD大鼠T11节段脊髓损伤模型,观察术后不同时间段脊髓内碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)蛋白表达分布及变化情况.结果:脊髓损伤各时间段bFGF阳性神经元数较正常组显著增加.7 d达高峰,21 d恢复正常.结论:脊髓损伤后bFGF表达,提示其参与了脊髓损伤后神经元的保护作用.
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| 关 键 词： | 碱性成纤维细胞生长因子 脊髓损伤 |
Expression change of basic fibroblast growth factor and its significance after experimental spinal cord injury in rat |
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| DENG Li , LI Ming. Expression change of basic fibroblast growth factor and its significance after experimental spinal cord injury in rat[J]. JOURNAL OF MODERN MEDICINE & HEALTH, 2011, 27(15): 2243-2244 |
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| Authors: | DENG Li LI Ming |
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| Affiliation: | DENG Li1,LI Ming2(1.Department of Neurobiology,Luzhou Medical College,Luzhou,Sichuan 646000,China,2.Department of Human Anatomy,Kunming Medical College,Kunming,Yunnan 650031,China) |
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| Abstract: | Objective:To study the mechanisms of self-repair following spinal cord injury(SCI).Methods:We adopted the T11 SCI model in SD rat by Allen's improved methods.Expressions and changes of basic fibroblast growth factor(bFGF) were observed in postoperative different time periods by immunohistochemical method.Results:bFGF positive neurons in SCI group during different time periods were significantly increased than those in the normal group,which reached the climax on 7d and restored to normal level on 21d.Conclu... |
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| Keywords: | Basic fibroblast growth factor(BFGF) Spinal cord injury(SCI) |
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