| 盐酸帕罗西汀对卒中后抑郁及神经功能恢复的影响 |
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| 引用本文： | 赵海霞,张冀萍,马建英,张亦凡. 盐酸帕罗西汀对卒中后抑郁及神经功能恢复的影响[J]. 武警医学院学报, 2010, 19(2): 111-113 |
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| 作者姓名： | 赵海霞 张冀萍 马建英 张亦凡 |
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| 作者单位： | 武警山西总队医院神经内科,山西,太原,030006 |
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| 摘 要： | 【目的】观察盐酸帕罗西汀对卒中后抑郁及神经功能恢复的影响。【方法】将95例急性卒中后抑郁患者随机分为盐酸帕罗西汀组（48例）和对照组（47例）,2组均接受常规药物治疗,治疗组同时加用盐酸帕罗西汀治疗。治疗前、治疗后4、8周应用Hamilton抑郁量表（HRSD）评价抑郁状况,采用简易智能状态量表（MMSE）、临床神经功能缺损程度评分（SSS）评价患者的认知和神经功能状况。【结果】治疗后4周、8周时盐酸帕罗西汀组HRSD总分比对照组显著降低（P〈0.01）,MMSE评分较对照组显著增加（P〈0.01）。盐酸帕罗西汀组治愈率和总有效率分别为61.22%和95.91%,显著高于对照组的15.213%和58.69%（P〈0.05）。治疗4周后两组SSS评分均有所下降,但无显著差异;治疗8周后盐酸帕罗西汀组SSS评分明显低于对照组（P〈0.01）。【结论】盐酸帕罗西汀治疗卒中后抑郁有效,能改善患者情感状态及促进神经功能恢复。
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| 关 键 词： | 盐酸帕罗西汀 卒中后抑郁 神经功能恢复 |
Effect of Paroxetine Hydrochloride on post-stroke depression and recovery of neurological function |
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| ZHAO Hai-xia,Zhang Ji-ping,Ma Jiany-ying,Zhang Yi-fan. Effect of Paroxetine Hydrochloride on post-stroke depression and recovery of neurological function[J]. Acta Academiae Medicinae CPAPF, 2010, 19(2): 111-113 |
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| Authors: | ZHAO Hai-xia Zhang Ji-ping Ma Jiany-ying Zhang Yi-fan |
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| Affiliation: | ZHAO Hai-xia,Zhang Ji-ping,Ma Jian-ying,Zhang Yi-fan(Department of Neurology,Shanxi Provincial Crops Hospital of Chinese People's Armed Police Force,Taiyuan 030006,China) |
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| Abstract: | [Objective]To observe the effect of Paroxetine Hydrochloride on post-stroke depression and recovery of neurological function.[Methods]A total of 95 patients of acute post-stroke depression were randomized into Paroxetine Hydrochloride group(48 cases)and control group(47 cases).Conventional therapy was given to both groups and to the treatment group Paroxetine Hydrochloride was given at the same time.Depression status was assessed with Hamilton Rating Depression Scale(HRSD),and cognitive and neurological fun... |
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| Keywords: | Paroxetine Hydrochloride Post-stroke depression Recovery of neurological function |
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