| 参麦注射液对盲肠结扎并穿孔致脓毒症大鼠的免疫调节作用 |
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| 引用本文： | 李蓉,程建祥.参麦注射液对盲肠结扎并穿孔致脓毒症大鼠的免疫调节作用[J].现代中西医结合杂志,2004,13(16):2135-2136. |
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| 作者姓名： | 李蓉 程建祥 |
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| 作者单位： | 1. 广东医学院,广东,湛江,524023
2. 广西医科大学,广西,南宁,530021 |
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| 摘 要： | 目的 探讨参麦注射液对盲肠结扎并穿孔 (CLP)引发脓毒症的免疫调节作用。方法 将大鼠随机分为正常对照组、CLP组、参麦组和生理盐水组 ,采用直接放射免疫分析法及酶联免疫吸附法分别测定血清皮质醇及肿瘤坏死因子 -α(TNF -α)含量 ,并行中性粒细胞(PMN)吞噬功能测定及白细胞移行抑制实验 (MIT)。结果 参麦注射液可提高PMN的吞噬率及改善胸腺指数、白细胞移行抑制指数 ,减少TNF -α过度释放 ,改善血清皮质醇水平。结论参麦注射液对盲肠结扎并穿孔引发脓毒症有免疫调节作用
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| 关 键 词： | 盲肠结扎并穿孔 脓毒症 参麦注射液 免疫功能 |
| 文章编号： | 1008-8849(2004)16-2135-02 |
| 修稿时间： | 2004年1月10日 |
Immune modulation effect of Shenmai injection on sepsis rats induced by cecal ligation and puncture |
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| LI Rong ,CHENG Jian-xiang.Immune modulation effect of Shenmai injection on sepsis rats induced by cecal ligation and puncture[J].Modern Journal of Integrated Chinese Traditional and Western Medicine,2004,13(16):2135-2136. |
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| Authors: | LI Rong CHENG Jian-xiang |
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| Institution: | LI Rong 1,CHENG Jian-xiang 2 |
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| Abstract: | Objective It is to study the immune modulation of Shenmai injection on sepsis induced by cecal ligation and puncture (CLP).Methods The rats were randomly divided into normal control group, CLP group, Shenmai group and physiological saline group. The content of serum cortisol and tumor necrosis factor-α(TNF-α) were measured with means of ELISA and RIA, and PMN Phagocytosis function mensuration and MIT were progressed.Results Shenmai injection could heighten the PMN phagocytosis rate, improve the thymus index and MII, reduce the excessive release of TNF-αand improve the level of serum cortisol.Conclusion Shenmai injection has immune modulation function on sepsis induced by CLP. |
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| Keywords: | cecal ligation and puncture sepsis Shenmai injection immune function |
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