Structural correlates of apathy in Alzheimer's disease |
| |
| Authors: | Apostolova Liana G Akopyan Gohar G Partiali Negar Steiner Calen A Dutton Rebecca A Hayashi Kiralee M Dinov Ivo D Toga Arthur W Cummings Jeffrey L Thompson Paul M |
| |
| Institution: | Department of Neurology, Laboratory of Neuro Imaging, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA. lapostolova@mednet.ucla.edu |
| |
| Abstract: | BACKGROUND: Apathy is the most common noncognitive symptom in Alzheimer's disease (AD). The structural correlates of apathy in AD have not yet been described. METHODS: We analyzed magnetic resonance imaging data of 35 AD patients with and without apathy. RESULTS: There was a significant linear association between apathy severity and cortical gray matter atrophy in the bilateral anterior cingulate Brodmann area (BA) 24; r = 0.39-0.42, p = 0.01] and left medial frontal cortex (BA 8 and 9; r = 0.4, p < 0.02). Left mean cingulate cortical thinning predicted the presence/absence of apathy at the trend level of significance. CONCLUSION: Our study demonstrates a strong association between apathy and the integrity of medial frontal regions in AD. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
