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| 鲜葛花汁对大鼠急性酒精性肝损伤的保护作用 | |
| 引用本文： | 侯光华,张介眉,时昭红,张晶,郝建军,陈洲.鲜葛花汁对大鼠急性酒精性肝损伤的保护作用[J].中国中西医结合消化杂志,2008,16(5). |
| 作者姓名： | 侯光华 张介眉 时昭红 张晶 郝建军 陈洲 |
| 作者单位： | 1. 湖北中医学院中医系,湖北,武汉,430061 2. 武汉市第一医院,消化内科 3. 武汉科技大学附属医院,急诊科,湖北,武汉,430081 |
| 基金项目： | 武汉市卫生局临床科研课题 |
| 摘 要： | 目的]观察鲜葛花汁对大鼠急性酒精性肝损伤的预防保护作用.方法]以单味葛花汤、益肝灵为对照,各组大鼠均先给予相应的药物灌胃,0.5 h后以白酒灌胃造成急性酒精性肝损伤模型,每天2次,连续灌胃7 d,第7天处死全部大鼠,检测血清和肝组织丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST),同时光镜观察肝组织病理形态学的改变.结果]鲜葛花汁能有效降低急性酒精性肝损伤模型大鼠血清及肝组织ALT、AST的升高,且作用显著优于对照组(P＜0.01);同时对大鼠肝组织病理形态学改变具有明显改善作用.结论]鲜葛花汁可用于治疗酒精及其他原因引起的肝损伤. |
| 关 键 词： | 鲜葛花汁 肝损伤 急性酒精性 肝组织 |
Protective effect of gehua fresh juice on rats with acute hepatic damage caused by alcohol |
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| HOU Guang-hua,ZHANG Jie-mei,SHI Zhao-hong,ZHANG Jing,HAO Jian-jun,CHEN Zhon.Protective effect of gehua fresh juice on rats with acute hepatic damage caused by alcohol[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2008,16(5). | |
| Authors: | HOU Guang-hua ZHANG Jie-mei SHI Zhao-hong ZHANG Jing HAO Jian-jun CHEN Zhon |
| Institution: | HOU Guang-hua1,ZHANG Jie-mei2,SHI Zhao-hong2,ZHANG Jing3,HAO Jian-jun2,CHEN Zhou1(1 Department of Tr,itional Chinese Medicine,Hubei College of Tr,itional ChineseMedicine,Wuhan 430061,China,2 Department of Gastroenterology,Wuhan NO.1Hospital,Wuhan 430022,3 Emergency Department,Affiliated Hospital ,Clinical College of Wuhan University of Science , Techology,Wuhan 430081,China) |
| Abstract: | Objective]To explore the protective effect of gehua fresh juice on rats with acute hepatic damage caused by alcohol.Methods]Compared with single gehua decoction and Yiganling,all of rats were first perfused with corresponding drugs,and then perfused with white wine to cause acute alcoholic liver damage.On the 7th day rats were sacrificed completely,and ALT,AST in sera and tissues were assayed.Simultaneously pathologic change of liver were examined.Results] Gehua fresh juice could effectively inhibit the ... |
| Keywords: | gehua fresh juice acute alcoholic hepatic damage liver tissue |
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