| 小窝蛋白-1、基质金属蛋白酶-2在膀胱癌的表达及其关系 |
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| 作者姓名： | Hengping Li Yirong Chen Dongwen Yan |
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| 作者单位： | [1]Department of Urology, Cancer Hospital of Gansu, Lanzhou 730050, China [2]Department of Urology, The People＇s Hospital of Gansu Province, Lanzhou 730000, China |
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| 摘 要： | Objective: To explore the expression of caveolin-1 (CAV-1) and matrix metalloproteinase-2 (MMP-2) in bladder cancer and its clinical significance. Methods: The expression of CAV-1 and MMP-2 were detected by the SP immunohistochemical method in 77 cases of bladder cancer. Results: The positive rates of CAV-1, MMP-2 in bladder transitional cell carcinoma (BTCC) and bladder adenocarcinoma were significantly high than those of normal bladder mucosa, the positive rates in the deeper cancer invasion was significantly high than those of superficial bladder cancer (P ＜ 0.01), the positive rates of CAV-1 in grades Ⅰ, Ⅱ and Ⅲ of bladder transitional cell carcinaoma (BTCC) were 15%, 40% and 68%, respectively;the positive rates of MMP-2 in grades Ⅰ, Ⅱ and Ⅲ of bladder transitional cell carcinoma (BTCC) were 20%, 40% and 72%,respectively (P ＜ 0.01). CAV-1 was positive associated with MMP-2 in bladder cancer (r= 0.598, P ＜ 0.001), but not in bladder tissue. Conclusion: CAV-1 and MMP-2 were associated with stage and grade of bladder cancer, which suggested that CAV-1might improve secretion of MMP-2.
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| 关 键 词： | 膀胱癌 治疗方法 癌细胞 化学疗法 |
| 收稿时间： | 2007-06-20 |
| 修稿时间： | 2007-08-03 |
Expression of caveolin-1 and MMP-2 in bladder cancer and its clinical significance |
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| Hengping Li Yirong Chen Dongwen Yan.Expression of caveolin-1 and MMP-2 in bladder cancer and its clinical significance[J].The Chinese-German Journal of Clinical Oncology,2007,6(6):571-573. |
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| Authors: | Hengping Li Yirong Chen Dongwen Yan |
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| Institution: | (1) Department of Urology, Cancer Hospital of Gansu, Lanzhou, 730050, China;(2) Department of Urology, The People’s Hospital of Gansu Province, Lanzhou, 730000, China |
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| Abstract: | Objective: To explore the expression of caveolin-1 (CAV-1) and matrix metalloproteinase-2 (MMP-2) in bladder cancer and its clinical significance. Methods: The expression of CAV-1 and MMP-2 were detected by the SP immunohis- tochemical method in 77 cases of bladder cancer. Results: The positive rates of CAV-1, MMP-2 in bladder transitional cell carcinoma (BTCC) and bladder adenocarcinoma were significantly high than those of normal bladder mucosa, the positive rates in the deeper cancer invasion was significantly high than those of superficial bladder cancer (P < 0.01), the positive rates of CAV-1 in grades I, II and III of bladder transitional cell carcinaoma (BTCC) were 15%, 40% and 68%, respectively; the positive rates of MMP-2 in grades I , II and III of bladder transitional cell carcinoma (BTCC) were 20% , 40% and 72%, respectively (P < 0.01). CAV-1 was positive associated with MMP-2 in bladder cancer (r = 0.598, P < 0.001), but not in bladder tissue. Conclusion: CAV-1 and MMP-2 were associated with stage and grade of bladder cancer, which suggested that CAV-1 might improve secretion of MMP-2. |
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| Keywords: | caveolin-1 MMP-2 bladder cancer immunohistochemistry |
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