| The Bacterial Inhibitory Ability and In Vivo Drug Release Pattern of a New Drug Delivery System:Ciprofloxacine/tricalcium Phosphate Delivery Capsule |
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| 引用本文： | 郑启新,吴宏斌,杜靖远,李世普,阎玉华. The Bacterial Inhibitory Ability and In Vivo Drug Release Pattern of a New Drug Delivery System:Ciprofloxacine/tricalcium Phosphate Delivery Capsule[J]. 华中科技大学学报(医学英德文版), 1998, 0(3) |
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| 作者姓名： | 郑启新 吴宏斌 杜靖远 李世普 阎玉华 |
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| 作者单位： | Department of Orthopedics，Xiehe Hospital，Tongji Medical University，Wuhan 430022;Biomaterials Center of Wuhan Technology University，Wuhan 430070 |
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| 摘 要： | Ahighandsustainedconcentrationofantibioticsatthesiteofinfectionisanidealwaytoachieveacureofmusculoskeletalinfections.Aseriesofimplantabledrugdeliverysystem(DDS)weredevelopedandsatisfactoryresultsweregainedbothinlaboratoryandinclinicalpractice.Theseincludedantibiotic--impregnated--polymetcrylate(PMMA)cement,antibioticloadedpolylacticacid/polyglycolicacid(PLA/PGA)copolymerandantibiotic--loadedporoushydroxyapatite(PHA)[l--4].Butsomelimitationswerealsoencounted=PMMAandPLA/PGAwerenotsobio…
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The Bacterial Inhibitory Ability and In Vivo Drug Release Pattern of a New Drug Delivery System:Ciprofloxacine/tricalcium Phosphate Delivery Capsule |
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| ZHENG Qixing, WU Hongbin, DU Jingyuan, LI Shipu, YAN Yuhua. The Bacterial Inhibitory Ability and In Vivo Drug Release Pattern of a New Drug Delivery System:Ciprofloxacine/tricalcium Phosphate Delivery Capsule[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 1998, 0(3) |
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| Authors: | ZHENG Qixing WU Hongbin DU Jingyuan LI Shipu YAN Yuhua |
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| Abstract: | The bacterial inhibitory ability of a new drug delivery system (DDS):Ciprofloxacine/tricalcium phosphate delivery capsule (CTDC), its in vivo drug release pattern, and the influence of ultrasonic irradiation on its drug release were investigated. It was found that CTDC had a strong and sustained inhibitory ability to some common pathogens of bone and joint infections, such as staphylococcus aureus, escherichia coli and pseudomonas aeruginosa. In vivo drug-release study in animals demonstrated a high concentration of ciprofloxacine in the bone tissue surrounding CTDC which was placed in the greater trochanter of the rabbit and continued to release ciprofloxacine for at least 5 weeks and the blood level of ciprofloxacine was low. In vivo study also showed ultrasonic irradiation could increase the amount of ciprofloxacine released from CTDC, which may be an economical, effecient and safe new method to achieve the control of drug release from DDS. |
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| Keywords: | drug delivery system tricalcium phosphate ciprofloxacine ultrasound |
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