| 多肽蛋白质类药物离子导入经皮给药的研究进展 |
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| 引用本文： | 朱姚亮,刘卫,陈华兵,杨祥良. 多肽蛋白质类药物离子导入经皮给药的研究进展[J]. 中国新药杂志, 2005, 14(12): 1394-1400 |
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| 作者姓名： | 朱姚亮 刘卫 陈华兵 杨祥良 |
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| 作者单位： | 华中科技大学生命科学与技术学院药物研究所,武汉,430074 |
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| 摘 要： | 论述了多肽蛋白质类药物离子导入经皮给药的特点及主要影响因素,重点介绍了近年来国际上对胰岛素、降血钙素、促黄体(生成)激素释放激素、精氨酸抗利尿激素(加压素)等多肽蛋白质类药物离子导入经皮给药的研究进展.
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| 关 键 词： | 多肽蛋白质类药物 离子导入 经皮给药 |
| 文章编号： | 1003-3734（2005）12-1394-07 |
| 修稿时间： | 2005-03-23 |
Advances in iontophoretic transdermal delivery of peptide and protein drugs |
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| ZHU Yao-liang,LIU Wei,CHEN Hua-bing,YANG Xiang-liang. Advances in iontophoretic transdermal delivery of peptide and protein drugs[J]. Chinese Journal of New Drugs, 2005, 14(12): 1394-1400 |
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| Authors: | ZHU Yao-liang LIU Wei CHEN Hua-bing YANG Xiang-liang |
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| Affiliation: | Institute of Materia Medica, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China |
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| Abstract: | It was shown that iontophoresis had significant enhancement on transdermal delivery of peptide and protein drugs.This review introduced the characteristics,transport mechanisms and influence factors of the iontophoretic transdermal drug delivery in respect to the advances on iontophoretic transdermal delivery of insulin,calcitonin,luteinizing hormone releasing hormone(LHRH) and vasopressin. |
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| Keywords: | peptide and protein drugs iontophoresis transdermal drug delivery |
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