| Abstract: | The isolated mice brain synaptosome was measured in vitro. The experiment explored protein biosynthesis by +3 H-Leu incorporation technique, meanwhile, the influence of Calmodulin(CaM) inhibitor Chlorpromazine(CPZ) on this toxicity was investigated as well. The result indicated that Cd prevented +3 H-Leu from incorporating into synaptosome, in which the concentration of Cd and the amount incorporated showed negative correlation and this toxic effect may be antagonized by CaM inibitor CPZ to some extend. It is concluded that CaM may be involved in the mechanism of Cd toxicity in brain synaptosome. |
