CD44与CD62P在肾脏疾病中的表达及意义

目的 探讨肾小球变患者外周血Ｐ选择素（ＣＤ６２Ｐ）与细胞表面糖蛋白（ＣＤ４４）的表达特征及临床意义。方法 采用流式细胞术对９０例肾脏疾病患者外周血ＣＤ６２Ｐ和ＣＤ４４进行检测分析，以３０例下沉人作为对照。结果 不同病因肾病患者ＣＤ６２Ｐ和ＣＤ４４表达 较正常组显著增高，其中慢性肾衰组ＣＤ４４阳性细胞数增高极为显著，ＩｇＡ肾病组ＣＤ６２Ｐ和ＣＤ４４表达均较其它肾脏疾病组降低，，肾病患者ＣＤ６２Ｐ和Ｃ

Expression and significance of CD44 and CD62P in patients with nephropathy

ObjectiveTo explore the expression and significance of Adhesion molecule P selectin (CD62P) and Adhesion molecule glycoprotein(CD44)in nephroses.MethodsThe expression of CD62P and CD44 in blood of nephropathy were assessed by flow cytometry,controled by 30 cases of normal people.ResultsCD62P and CD44 in primary glomerular nelphritis blood showed higher level than that in the control( P <0 01),while CD44 in chronic renal failure group was especially higher.Compared with other nephropathy groups,expressions of CD62P and CD44 in IgA nephropathy group were lower.And expressions of CD62P and CD44 in primary glomerular nephritis patients were correlated with each other( r =0 41, P <0 05).ConclusionCD62P and CD44 expressed higher in the blood of glomerular nelphritis patients,which may play an important role in the progress of renal disease.