丹参素对猪离体冠状动脉的作用

近来,从丹参中分离得一种新的水溶性成分β(3,4-二羟基苯墓)乳酸(即丹参素)。我们用改良的Ogletree等的离体冠状动脉恒速灌流制备,与后者不同处是将离体冠状动脉段两端均结扎在灌流制备套管上。本文研究丹参素和丹参另一些成分如:丹参酮Ⅱ-A磺酸

EFFECT OF DANSHENSU ON ISOLATED SWINE CORONARY ARTERY PERFUSION PREPARATION

In a constant pressure perfused swine coronary artery preparation, Danshensu, β(3,4-dihydroxyphenyl) lactic acid a constituent from S. miltiorrhiza Bge was found to dilate the coronary artery and antagonize significantly the constricting responses elicited by doses of morphine and propranolol. These interactions might be of practical importance when either propranol or morphine is administered concomitantly with Danshensu in treating severe angina episodes. In this experiment, the morphine-induced coronary constriction seemed to bear no relation to histamine or opiate receptors, since it was neither antagonized by the antihistamine agent (Antazoline) nor by naloxone. Although the propranolol induced coronary constriction was speculated partly due to the alpha adrenoreceptor dominance accompanying beta-blockade, the mechanism of antagonism by Danshensu remains to be investigated. In addition, Danshensu showed no antagonistic effect on the contracture response of coronary artery elicited by high potassium medium.