血栓通注射液联合尿激酶治疗下肢深静脉血栓形成的临床观察

目的:观察血栓通注射液联合尿激酶对下肢深静脉血栓形成的临床疗效。方法:56例下肢深静脉血栓形成患者均分为2组,对照组常规采用尿激酶溶栓,低分子肝素钙抗凝,阿司匹林祛聚,低分子右旋糖酐扩容;治疗组在对照组基础上加用血栓通注射液治疗。治疗后观察、比较2组疗效及相关指标。结果:2组患者溶栓后下肢静脉通畅率比较无显著性差异(P>0.05);2组患者溶栓后血液黏度较溶栓前显著下降,同时治疗组患者血液黏度下降更低,与对照组比较差异有统计学意义(P<0.05);治疗组皮下出血、内脏出血、皮肤过敏、发热反应发生率均略高于对照组,但2组间比较,差异无统计学意义(P>0.05);对照组于随访期内下肢浅静脉曲张、下肢深静脉瓣膜功能不全发生率高于治疗组(P<0.05);对照组足靴区皮肤色素沉着、下肢行走时疼痛发生率也高于治疗组,但2组比较差异无统计学意义(P>0.05)。结论:血栓通注射液联合尿激酶治疗下肢深静脉血栓形成,可发挥较好的协同作用,远期效果好。

Clinical Observation of Xueshuantong Injection Combined with Urokinase on the Formation of Deep Venous Thrombosis

OBJECTIVE:To investigate clinical efficacy of Xueshuantong injection combined with urokinase on the formation of deep venous thrombosis.METHODS:56 cases of deep venous thrombosis were divided into control group and treatment group,28 cases in the control group conventional urokinase thrombolysis,low molecular weight heparin anticoagulation,aspirin,antiplatelet adhesion,low molecular weight dextran expansion.Treatment group on the basis of the control group plus treated with Xueshuantong injection.RESULTS:After treatment,the patency rates between the 2 groups have no significant differences(P>0.05);Blood viscosity in the 2 groups of patients after thrombolysis compared with before thrombolysis significantly decline,in the treatment group with lower blood viscosity,compared with the control group were significantly different(P<0.05);Compared with control group,the subcutaneous hemorrhage,internal bleeding,allergic reactions,fever reactions were slightly higher in treatment group(P>0.05);When follow-up,the high incidence of lower extremity varicose veins,lower extremity deep venous valve insufficiency was higher in control group(P<0.05);The control group of treads area skin pigmentation,the incidence of pain in the lower limbs when walking is also higher than the treatment group,but the difference between 2 groups was not significant(P>0.05).CONCLUSION:Application Xueshuantong on the basis of the urokinase joint treatment of deep vein thrombosis,can play a good synergy,and the forward effect is better than the traditional western medicine therapy.