Yellow fever vaccine |
| |
| Authors: | Nicola M. Tauraso Sheldon L. Spector Roy W. Trimmer |
| |
| Affiliation: | (1) Present address: Department of Health Education, and Welfare Public Health Service, National Institutes of Health, Division of Biologics Standards, Laboratory of Virology and Rickettsiology Arbovirus Unit, Bethesda, Maryland, USA |
| |
| Abstract: | Summary Removal of avian leukosis viruses (ALV), which have contaminated the yellow fever (YF) 17 D vaccine since its development in the middle 1940's, had no effect upon the antigenicity of this vaccine in rhesus monkeys. From results of plaque neutralization tests, the high degree of antigenicity of the 17 D vaccine was confirmed.Pre-existing cross-reacting antibodies to other antigenically related arboviruses did not interfere with the antibody response to YF vaccine. However, administration of YF vaccine did elicit antibodies capable of cross-reacting with West Nile, and less so with Langat, arbovirus antigens. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
