MR imaging of renal cell carcinoma: associations among signal intensity, tumor enhancement, and pathologic findings |
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Authors: | Yabuki Takayuki Togami Izumi Kitagawa Takahiro Sasai Nobuya Tsushima Tomoyasu Shirasaki Yoshinori Hiraki Yoshio |
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Affiliation: | Department of Radiology, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan. radiol@cc.okayama-u.ac.jp |
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Abstract: | The purpose of this study was to compare the MR characteristics of renal cell carcinomas against histologic findings and to assess the correlations among signal intensity, tumor enhancement, and pathologic findings. Fifty-four patients (56 lesions) were examined by MR imaging and then underwent partial or radical nephrectomy. The pathologic diagnosis of all lesions was renal cell carcinoma. All MR examinations were performed as dynamic studies using the same 1.5-T scanner. MR characteristics were compared against pathologic findings after resection, and the correlations among signal intensity, tumor enhancement, and pathologic findings were then assessed. A significant correlation was observed between tumor grade and tumor enhancement, with G3 lesions tending to show little enhancement. Regardless of the histologic classification, G3 tumors were found to contain highly heterotypic cancer cells and very few vessels by histopathologic examination. No significant correlations were noted between the other MR characteristics and pathologic findings. Renal cell carcinomas showing little enhancement tend to be highly malignant lesions based on the pathologic findings. Special consideration is required for these tumors with regard to the selection of surgical intervention and follow-up observation. |
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