Serotype,virulence profile,antimicrobial resistance and macrolide-resistance determinants in Streptococcus agalactiae isolates in pregnant women and neonates in Catalonia,Spain |
| |
Authors: | Yuly López Elena Parra Virginio Cepas Isabel Sanfeliú Teresa Juncosa Antonia Andreu Mariona Xercavins Josefa Pérez Sergi Sanz Andrea Vergara Jordi Bosch Sara Maria Soto |
| |
Institution: | 1. Barcelona Institute for Global Health (ISGlobal) – Hospital Clínic-Universitat de Barcelona, Barcelona, Spain;2. Hospital Parc Taulí de Sabadell, Barcelona, Spain;3. Hospital Sant Joan de Déu, Barcelona, Spain;4. Hospital Universitari Vall d’Hebron, Barcelona, Spain;5. CatLab, Hospital Mutua de Terrassa, Barcelona, Spain;6. Department of Microbiology, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain |
| |
Abstract: | IntroductionStreptococcus agalactiae, or group B streptococci (GBS), is the main aetiological agent of early neonatal sepsis in developed countries. This microorganism belongs to the gastrointestinal tract microbiota wherefrom it can colonize the vagina and be vertically transmitted to the child either before or at birth, and subsequently cause infection in the newborn. Approximately, 50% of newborns born to women with GBS become colonized, with 1–2% developing early neonatal infection if no preventive intervention is performed. The aim of this study was to characterize and compare serotypes, virulence factors and antimicrobial resistance of GBS isolates collected from pregnant women and newborns in several hospitals in Catalonia.Methods242 GBS strains were analyzed including 95 colonizers and 68 pathogenic strains isolated from pregnant women, and 79 strains isolated from neonates with sepsis in order to determine serotype, virulence and antimicrobial resistance.ResultsSerotype distribution was different among the three groups, with serotypes Ia and II being significantly more frequent among colonizing strains (p = 0.001 and 0.012, respectively). Virulence factors bca and scpB were significantly more frequent among neonatal strains than pathogenic or colonizing strains (p = 0.0001 and 0.002, respectively). Pathogenic strains were significantly more resistant to erythromycin, clindamycin and azithromycin than their non-pathogenic counterparts.ConclusionsTaking into account that neonatal sepsis represents a significant problem on a global scale, epidemiological surveillance, antimicrobial resistance and GBS virulence at the local level could provide important knowledge about these microorganisms as well as help to improve treatment and prevent invasive infection caused by this microorganism. |
| |
Keywords: | Virulence Serotypes Antimicrobial resistance Virulencia Serotipos Resistencia antimicrobiana Corresponding author |
本文献已被 ScienceDirect 等数据库收录! |
|