Potentially bioactive two new natural sesquiterpenoids from the rhizomes ofZingiber zerumbet |
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Authors: | Dae Sik Jang Eun-Kyoung Seo |
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Institution: | Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea. |
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Abstract: | Repeated chromatography of the n-hexane-soluble fraction of the MeOH extract of the rhizomes of Zingiber zerumbet led to the isolation of two isomers of 6-methoxy-2E,9E-humuladien-8-one (1 and 2) and stigmast-4-en-3-one. The structures of 1 and 2 were determined by spectroscopic methods including 1 D and 2D-NMR elucidated by analysis of spectroscopic data as well as by comparison with published values. This is the first report on the isolation of compounds 1 and 2 from the nature. Stigmast-4-en-3-one was first isolated from this plant. |
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Keywords: | Zingiber zerumbet Zingiberaceae Sesquiterpenoids 6-Methoxy-2E 9E-humula-dien-8-one Stigmast-4-en-3-one |
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